Fracture Risk After Gastric Bypass Surgery: A Retrospective Cohort Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Kristian F AxelssonMattias Lorentzon

Abstract

Gastric bypass surgery constitutes the most common and effective bariatric surgery to treat obesity. Gastric bypass leads to bone loss, but fracture risk following surgery has been insufficiently studied. Furthermore, the association between gastric bypass and fracture risk has not been studied in patients with diabetes, which is a risk factor for fracture and affected by surgery. In this retrospective cohort study using Swedish national databases, 38,971 obese patients undergoing gastric bypass were identified, 7758 with diabetes and 31,213 without. An equal amount of well-balanced controls were identified through multivariable 1:1 propensity score matching. The risk of fracture and fall injury was investigated using Cox proportional hazards and flexible parameter models. Fracture risk according to weight loss and degree of calcium and vitamin D supplementation 1-year postsurgery was investigated. During a median follow-up time of 3.1 (interquartile range [IQR], 1.7 to 4.6) years, gastric bypass was associated with increased risk of any fracture, in patients with and without diabetes using a multivariable Cox model (hazard ratio [HR] 1.26; 95% CI, 1.05 to 1.53; and HR 1.32; 95% CI, 1.18 to 1.47; respectively). Using flexible p...Continue Reading

References

Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
Nov 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel Prieto-AlhambraAdolfo Díez-Pérez
Aug 8, 2012·BMJ : British Medical Journal·Arief LalmohamedNicholas C Harvey
Aug 6, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K M NakamuraK A Kennel
Sep 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M P Hage, G El-Hajj Fuleihan
Mar 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W Yu
Jun 11, 2014·JAMA : the Journal of the American Medical Association·Lars SjöströmLena M S Carlsson
Jan 21, 2015·American Journal of Surgery·Christopher A GuidryPeter T Hallowell
Feb 24, 2015·Obesity Surgery·J L HedenbroI Näslund
Apr 3, 2015·Journal of Internal Medicine·M Lorentzon, S R Cummings
Dec 4, 2015·Medicine·Chia-Wen LuKuo-Chin Huang
Apr 27, 2016·Basic & Clinical Pharmacology & Toxicology·Susanna M WallerstedtMikael Hoffmann
Jun 9, 2016·JAMA : the Journal of the American Medical Association·Katherine M FlegalCynthia L Ogden
Aug 25, 2016·The American Journal of Medicine·Jennifer PanosianAllison B Goldfine
Nov 1, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Märit WallanderMattias Lorentzon
Nov 5, 2016·BMJ : British Medical Journal·Catherine RousseauClaudia Gagnon
Mar 3, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elaine W YuSeoyoung C Kim
Mar 16, 2017·European Journal of Endocrinology·Vikram V ShanbhogueStinus Hansen
Apr 14, 2017·Obesity Surgery·L AngrisaniN Scopinaro
Aug 10, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tiffany Y KimAnne L Schafer
Sep 21, 2017·The New England Journal of Medicine·Ted D AdamsSteven C Hunt
Jan 18, 2018·JAMA : the Journal of the American Medical Association·David Arterburn, Anirban Gupta

❮ Previous
Next ❯

Citations

Nov 6, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Toshihiro Sugiyama
Nov 7, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Kristian F Axelsson, Mattias Lorentzon
May 8, 2019·Journal of Palliative Medicine·Jennifer GabbardBuddy Marterre
Jun 20, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ingvild Kristine Blom-HøgestølErik Fink Eriksen
Mar 2, 2019·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Bruno Halpern, Marcio Correa Mancini
Feb 12, 2020·Obesity Surgery·Daniel CottamDennis Smith
Jul 15, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Katherine G LindemanElaine W Yu
Jun 11, 2020·JAMA Network Open·Syed I KhalidAlfonso Torquati
May 14, 2019·Endocrine Reviews·Marjon A SmitSnježana Kos
Jun 20, 2019·Expert Review of Endocrinology & Metabolism·Tummas JustinussenKirstine Nyvold Bojsen-Møller
Jul 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Igor H MuraiBruno Gualano
Apr 15, 2020·Current Osteoporosis Reports·William D Leslie, Suzanne N Morin
Mar 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Eric LespessaillesUNKNOWN GRIO Scientific Committee
Aug 28, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Malgorzata M BrzozowskaJacqueline R Center
Apr 13, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C NypaverS Mehta
Mar 19, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Julien PaccouGrégoire Ficheur
Oct 15, 2019·Frontiers in Endocrinology·Isabel Cornejo-ParejaFrancisco J Tinahones
Nov 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Dag HofsøJøran Hjelmesæth
Jan 27, 2021·Endocrinología, Diabetes Y Nutrición·Mirian Alejo RamosIsidoro M Cano Rodríguez
Jan 7, 2021·Calcified Tissue International·Julien PaccouBernard Cortet
Nov 18, 2018·Metabolism: Clinical and Experimental·Charles J Glueck, Naila Goldenberg
Jun 26, 2021·Endocrinología, Diabetes Y Nutrición·Mirian Alejo RamosIsidoro M Cano Rodríguez
Jun 27, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Danielle E RobinsonDaniel Prieto-Alhambra
Sep 4, 2021·Endocrine Reviews·Peter R EbelingFrances Milat
Nov 10, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Julie KimUNKNOWN American Society for Metabolic and Bariatric Surgery (ASMBS) Clinical Issues Committee
Dec 11, 2021·The Journal of Clinical Endocrinology and Metabolism·Karin C WuAnne L Schafer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.