Fracture risk of women with primary biliary cirrhosis: no increase compared with general population controls

Alimentary Pharmacology & Therapeutics
J R Boulton-JonesS D Ryder

Abstract

Patients with primary biliary cirrhosis may be at increased risk of osteoporosis but to what extent this is reflected in an increased fracture risk is unknown. We have enquired about the fracture experience of female primary biliary cirrhosis patients compared with sex- and age-matched controls. Patients aged 30-75 with primary biliary cirrhosis and age-matched controls were sent a postal questionnaire asking about their fracture history and details of risk factors for osteoporosis. 85 eligible patients with primary biliary cirrhosis and 116 controls responded. Forty-one per cent of patients with primary biliary cirrhosis and 30% of controls reported ever having had a fracture odds ratio 1.5 (95% confidence interval: 0.80-2.89). Twenty-eight per cent of primary biliary cirrhosis patients and 23.3% of controls reported a fracture after the age of 30, odds ratio 1.2 (95% confidence interval: 0.57-2.56), and 14.1% of primary biliary cirrhosis patients and 12.1% of controls reported a low impact fracture of the long bones or of the vertebrae odds ratio 1.0 (95% confidence interval: 0.31-2.68). No overall increased fracture risk in patients with primary biliary cirrhosis was observed. As a group, unselected patients with primary bil...Continue Reading

References

Aug 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R EastellR A Krom
Feb 1, 1988·Gastroenterology·H C MitchisonO F James
Dec 1, 1985·Annals of Internal Medicine·S F HodgsonB L Riggs
Feb 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K D LindorE R Dickson
Apr 23, 1999·Journal of Gastroenterology·S ShiomiH Ochi
May 20, 1999·European Journal of Gastroenterology & Hepatology·S P PereiraR Williams
May 5, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D HowelO F James
Dec 29, 2000·Journal of Hepatology·K D LindorE R Dickson
Mar 7, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A ParésJ Rodés
Jul 17, 2001·Gut·J NewtonD Jones
Oct 31, 2001·Calcified Tissue International·K D Ward, R C Klesges
Dec 1, 2001·Bone·T P van StaaC Cooper
Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton

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Citations

Sep 24, 2005·The New England Journal of Medicine·Marshall M Kaplan, M Eric Gershwin
May 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Edmée C M SikkensMarco J Bruno
May 7, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ulrich Christian BangJens-Erik Beck Jensen
May 6, 2008·Clinics in Liver Disease·Teru Kumagi, Morikazu Onji
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorUNKNOWN American Association for Study of Liver Diseases
Nov 8, 2006·Gastroenterology·Masoud Solaymani-DodaranJoe West
Mar 16, 2018·PloS One·Chen-Yi LiaoWu-Chien Chien
Dec 14, 2011·The Cochrane Database of Systematic Reviews·Jelena S RudicChristian Gluud
Sep 28, 2017·Clinical Rheumatology·Junyu FanLingyun Sun
Oct 22, 2020·Curēus·Diego F HidalgoJessica Hidalgo
Nov 28, 2020·BMC Musculoskeletal Disorders·Kuang-Ting YehWen-Tien Wu

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