Fragile site induction by aphidicolin may be increased in parents of neuroblastoma patients

Cancer Genetics and Cytogenetics
P VernoleB Nicoletti

Abstract

We recently demonstrated an increased expression of fragile sites, induced by aphidicolin, in lymphocytes of neuroblastoma patients. We have now extended our studies to parents of affected children with neuroblastoma to verify if this characteristic may be genetically transmitted. We have examined 20 families. In most of them, the hypersensitivity to aphidicolin was found in the affected child and in at least one parent. Moreover, some of the parents showed an increase in the expression of the fragile sites 1p32, 1p13, or both that are preferentially expressed in neuroblastoma patients. The possible relations between the hypersensitivity to aphidicolin and the inheritance of predisposition to neuroblastoma must be clarified.

References

May 1, 1989·Human Genetics·Y Sugio, Y Kuroki
Mar 1, 1988·Cancer Genetics and Cytogenetics·A H PuspursG R Sutherland
Jun 1, 1987·American Journal of Medical Genetics·B TedeschiB Nicoletti
Nov 1, 1988·Cancer Genetics and Cytogenetics·P VernoleB Nicoletti
Jan 1, 1987·Cytogenetics and Cell Genetics·C D BloomfieldH van den Berghe
Sep 1, 1985·Cancer Genetics and Cytogenetics·F ShabtaiI Halbrecht
Oct 30, 1971·Lancet·M Seabright
Dec 7, 1984·Science·J J Yunis, A L Soreng
Nov 1, 1982·Cancer Genetics and Cytogenetics·F HechtJ D Cohen

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Citations

Jun 1, 1993·Cancer Genetics and Cytogenetics·C ArdisiaE Donti
Oct 1, 1995·Cancer Genetics and Cytogenetics·T S Sundareshan, M Augustus
Jun 1, 1997·Cancer Genetics and Cytogenetics·U EgeliN Ozyardímcí
Jun 27, 2000·Cancer Genetics and Cytogenetics·B TuncaA Kizil
Mar 25, 2000·Clinical Genetics·P VernoleP Grimaldi
May 15, 2002·Genes, Chromosomes & Cancer·Constance K SteinBonnie S Glisson
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·M KaradağO Gözü
Apr 12, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Berrin TuncaIlker Ercan

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