Fragment-based screening: a promising avenue for drug design

Médecine sciences : M/S
Isabelle Krimm

Abstract

Fragment-based screening is now recognised as a powerful method for the design of novel potent molecules against therapeutic protein targets including challenging targets. Here, the main concepts used in the fragment-based drug design approach are reviewed, together with the reasons for its success. Methods and strategies used to identify, validate and select fragments are discussed. Future challenges and developments that are expected for the next decade are presented.

References

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Citations

Apr 10, 2015·Médecine sciences : M/S·Olivier SperandioPhilippe Roche

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