Frailty and Mortality Outcomes in Cognitively Normal Older People: Sex Differences in a Population-Based Study

Journal of the American Geriatrics Society
Mairead M BartleyRonald C Petersen

Abstract

To characterize frailty in cognitively normal older adults at baseline and to investigate the relationship between frailty and mortality. Population-based prospective cohort study: Mayo Clinic Study of Aging. Olmsted County, Minnesota. Cognitively normal older persons aged 70 and older (mean age 78.8±5.2, 50.2% male; N=2,356). Frailty was assessed at baseline using a 36-item Frailty Index. Four frailty subgroups were identified based on the Frailty Index (≤0.10 (fit), 0.11-0.20 (at risk), 0.21-0.30 (frail), >0.30 (frailest)). All participants underwent comprehensive clinical and cognitive assessments. The association between frailty and mortality was assessed using Cox proportional hazards models. The median Frailty Index was 0.17 (interquartile range 0.11-0.22). Frailty increased with age and was more common in older men than in older women. Over a median follow-up of 6.5 years (range 7 days to 8.9 years), 500 of the 2,356 participants died, including 292 men. The frailest participants had the greatest risk of death (hazard ratio (HR)=3.91, 95% confidence interval (CI)=2.69-5.68). The association was stronger in women (HR=5.26, 95% CI=2.88-9.61) than men (HR=3.15, 95% CI=1.98-5.02). Baseline frailty was common, especially in o...Continue Reading

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Citations

Oct 21, 2016·Journal of the American Geriatrics Society·Wolfgang von Renteln-Kruse, Christoph E Minder
Oct 13, 2017·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·Ching Hwa HsuTsae-Jyy Wang
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Jul 20, 2020·Journal of the American Medical Directors Association·Yu FanDandan Gong
Feb 17, 2021·Geriatrics & Gerontology International·Wei-Min ChuMeng-Chih Lee
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Jul 30, 2021·Mechanisms of Ageing and Development·Alice E Kane, Susan E Howlett

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