Frailty and the endocrine system

The Lancet. Diabetes & Endocrinology
Andrew Clegg, Zaki Hassan-Smith

Abstract

Frailty is a condition characterised by loss of biological reserves, failure of homoeostatic mechanisms, and vulnerability to adverse outcomes. The endocrine system is considered particularly important in frailty, because of its complex inter-relationships with the brain, immune system, and skeletal muscle. This Review summarises evidence indicating a key role for the hypothalamic-pituitary axis in the pathogenesis of frailty through aberrant regulation of glucocorticoid secretion, insulin-like growth factor signalling, and androgen production. Evidence also indicates a potential role for vitamin D and insulin resistance in the pathogenesis of frailty. The role of thyroid hormones in the pathogenesis of frailty remains uncertain. Key convergent pathological effects of frailty include loss of muscle mass and strength, with consequent impact on mobility and activities of daily living. Future translational research should focus on the understanding of endocrine mechanisms, to identify potential biomarkers of the condition, modifiable targets for treatment, and novel pharmacological drugs targeted at the endocrine components of frailty.

Citations

Nov 6, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Mariam El AssarLeocadio Rodríguez Mañas
Jan 30, 2019·Diabetes Care·Guowei LiUNKNOWN CaMos Research Group
May 17, 2019·Clinical Medicine : Journal of the Royal College of Physicians of London·Matthew HaleAndrew Clegg
Oct 2, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Vicky Kamwa, Zaki K Hassan-Smith
Oct 9, 2019·The Journal of Physiology·Guadalupe L Rodríguez-GonzálezElena Zambrano
Oct 18, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Marta Gutiérrez-Valencia, Nicolás Martínez-Velilla
Jan 30, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Guowei LiUNKNOWN Canadian Multicentre Osteoporosis Study (CaMos) Research Group
Jul 11, 2019·Praxis·Christoph Henzen
May 14, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Katherine ChabotFranco Carli
Nov 26, 2019·Shock·Bellal Joseph, Thomas Scalea
May 13, 2020·Current HIV/AIDS Reports·Julian Falutz
Oct 18, 2019·Aging & Mental Health·Rachael FrostKate Walters
Aug 10, 2020·Anesthesia and Analgesia·Marie E Csete
Nov 22, 2019·Experimental Gerontology·Riccardo CalvaniUNKNOWN European MID-Frail Consortium
Nov 17, 2020·Frontiers in Immunology·Francesca MottaCarlo Selmi
Dec 29, 2020·Nutrition Reviews·Kalliopi K GkouskouAristides G Eliopoulos
Feb 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Jan 30, 2021·The British Journal of Nutrition·Rachel E NealeLouisa G Gordon
May 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Wen-Qing XieYu-Sheng Li
Jun 29, 2021·The Journal of Nutrition, Health & Aging·X Lv, H Niu
Jun 16, 2021·Journal of the American Medical Directors Association·Bing-Ru DongZhi-Gang Pan
Apr 6, 2021·Aging and Disease·Stefano RizzaMassimo Federici
Aug 22, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Virginie ChuyCatherine Féart
Feb 3, 2022·European Geriatric Medicine·Xuchao PengJirong Yue

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