Frailty as a predictor of the incidence and course of depressed mood

Journal of the American Medical Directors Association
Rose M CollardRichard C Oude Voshaar

Abstract

Late-life depression and physical frailty are supposed to be reciprocally associated, however, longitudinal studies are lacking. This study examines whether physical frailty predicts a higher incidence of depression, as well as a less favorable course of depression. A population-based cohort study of 888 people aged 65 years and over with follow-up measures at 3, 6, and 9 years. Cox proportional hazards models adjusted for age, sex, education, smoking, alcohol usage, and global cognitive functioning were applied to calculate the incidence of depressed mood in those nondepressed at baseline (n = 699) and remission in those with depressed mood at baseline (n = 189). Depressed mood onset or remission was defined as crossing the cut-off score of 20 points on the Center for Epidemiological Studies-Depression Scale combined with a relevant change in this score. Physical frailty was based on the presence of ≥ 3 out of 5 components (ie, weight loss, weakness, slowness, exhaustion, and low physical activity level). A total of 214 out of 699 (30.6%) nondepressed persons developed depressed mood during follow-up. Physical frailty predicted the onset of depressed mood with a hazard rate of 1.26 (95% confidence interval 1.09-1.45, P = .002)...Continue Reading

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Citations

May 3, 2015·Journal of the American Medical Directors Association·John E Morley
May 29, 2016·Journal of the American Medical Directors Association·John E Morley
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Sep 1, 2021·European Psychiatry : the Journal of the Association of European Psychiatrists·R C Oude VoshaarH W Jeuring

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