Frailty Factors and Outcomes in Vascular Surgery Patients: A Systematic Review and Meta-analysis.

Annals of Surgery
John S M HoughtonRob D Sayers

Abstract

To describe and critique tools used to assess frailty in vascular surgery patients, and investigate its associations with patient factors and outcomes. Increasing evidence shows negative impacts of frailty on outcomes in surgical patients, but little investigation of its associations with patient factors has been undertaken. Systematic review and meta-analysis of studies reporting frailty in vascular surgery patients (PROSPERO registration: CRD42018116253) searching Medline, Embase, CINAHL, PsycINFO, and Scopus. Quality of studies was assessed using Newcastle-Ottawa scores (NOS) and quality of evidence using Grading of Recommendations Assessment, Development, and Evaluation criteria. Associations of frailty with patient factors were investigated by difference in means (MD) or expressed as risk ratios (RRs), and associations with outcomes expressed as odds ratios (ORs) or hazard ratios (HRs). Data were pooled using random-effects models. Fifty-three studies were included in the review and only 8 (15%) were both good quality (NOS ≥ 7) and used a well-validated frailty measure. Eighteen studies (62,976 patients) provided data for the meta-analysis. Frailty was associated with increased age [MD 4.05 years; 95% confidence interval (...Continue Reading

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Citations

Nov 6, 2020·Journal of the American Geriatrics Society·Janani ThillainadesanVasi Naganathan
Feb 13, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·John S M HoughtonRob D Sayers
Sep 11, 2020·Age and Ageing·Towhid ImamSimon Conroy
Jan 3, 2021·Journal of Vascular Surgery·Louise B D BanningRobert A Pol
Jan 11, 2021·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Christophe Alain FehlmannDebra Eagles
Feb 8, 2021·Annals of Vascular Surgery·Michael CiaramellaWilliam Beckerman
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May 27, 2021·Transplantation Direct·Evelien E QuintRobert A Pol
Jun 27, 2021·The Journal of Surgical Research·Janani ThillainadesanVasi Naganathan

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