Frailty Hinders Recovery From Influenza and Acute Respiratory Illness in Older Adults.

The Journal of Infectious Diseases
Caitlin LeesMelissa K Andrew

Abstract

We examined frailty as a predictor of recovery in older adults hospitalized with influenza and acute respiratory illness. A total of 5011 patients aged ≥65 years were admitted to Canadian Serious Outcomes Surveillance Network hospitals during the 2011/2012, 2012/2013, and 2013/2014 influenza seasons. Frailty was measured using a previously validated frailty index (FI). Poor recovery was defined as death by 30 days postdischarge or an increase of more than 0.06 (≥2 persistent new health deficits) on the FI. Multivariable logistic regression controlled for age, sex, season, influenza diagnosis, and influenza vaccination status. Mean age was 79.4 (standard deviation = 8.4) years; 53.1% were women. At baseline, 15.0% (n = 750) were nonfrail, 39.3% (n = 1971) were prefrail, 39.8% (n = 1995) were frail, and 5.9% (n = 295) were most frail. Poor recovery was experienced by 21.4%, 52.0% of whom had died. Frailty was associated with lower odds of recovery in all 3 seasons: 2011/2012 (odds ratio [OR] = 0.70; 95% confidence interval [CI], 0.59-0.84), 2012/2013 (OR = 0.72; 95% CI, 0.66-0.79), and 2013/2014 (OR = 0.75; 95% CI, 0.69-0.82); results varied by season, influenza status, vaccination status, and age. Increasing frailty is associate...Continue Reading

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Citations

Nov 21, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Alessandra MarengoniGraziano Onder
May 7, 2021·Clinical Interventions in Aging·Melissa K AndrewJanet E McElhaney
Jun 19, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rocco BarazzoniUNKNOWN endorsed by the ESPEN Council

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