Frailty in Parkinson's Disease: A Systematic Review

Journal of Parkinson's Disease
Natalie SmithEmily Henderson

Abstract

Parkinson's disease (PD) and frailty are two conditions that are increasingly common with advancing age, yet little is known about their relationship. The aim of this study was to examine the co-occurrence of frailty in people with PD; to describe the measures used to assess frailty in PD, and assess the prevalence of frailty in subjects with PD. We conducted a systematic review of Pubmed and Embase in April 2018. Studies that assessed frailty in subjects with PD were included in the review and data was extracted on the prevalence of frailty in subjects with PD. Due to heterogeneity of studies a meta-analysis was not performed. Eight studies were included in the review, of which 7 were cross-sectional and 1 a prospective cohort study. Mean age of participants with PD in the studies ranged from 66 to 85 years. The majority (6/8) used the 5-item, Fried criteria to measure frailty, with the remainder using index-based measures. 5 studies provided data on the prevalence of frailty in PD, which ranged from 29% to 67%. Few studies have quantified the prevalence of frailty in PD, but those that have suggest a high concurrence of these two conditions.

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Feb 21, 2006·Lancet Neurology·K Ray ChaudhuriUNKNOWN National Institute for Clinical Excellence
Jul 20, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth Rockwood, Arnold Mitnitski
Jul 21, 2007·Journal of Neural Transmission·R CamicioliK Rockwood
Nov 9, 2007·Parkinsonism & Related Disorders·Nasiya N AhmedDavid Vanwyck
Jan 1, 2008·The Journal of Nutrition, Health & Aging·G Abellan van KanB Vellas
Mar 14, 2012·Journal of the American Geriatrics Society·Kaitlyn P RolandColin Powell
Apr 19, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Leocadio Rodríguez-MañasUNKNOWN FOD-CC group (Appendix 1)
Aug 25, 2012·Journal of Aging Research·Kaitlyn P RolandGareth R Jones
May 3, 2013·Neurology·Aron S BuchmanDavid A Bennett
Sep 26, 2013·Archives of Gerontology and Geriatrics·Kaitlyn P RolandJennifer M Jakobi
Oct 25, 2013·The Journal of Nutrition, Health & Aging·E KelaiditiUNKNOWN IANA/IAGG
Oct 15, 2014·Age and Ageing·Catharine R GaleAvan Aihie Sayer
Dec 7, 2016·JAMA : the Journal of the American Medical Association·Lisa S RotensteinDouglas A Mata

❮ Previous
Next ❯

Citations

Nov 19, 2019·Frontiers in Aging Neuroscience·Wei-Che LinCheng-Hsien Lu
Aug 4, 2020·Journal of Parkinson's Disease·Emma Tenison, Emily J Henderson
Jan 30, 2021·Journal of Geriatric Psychiatry and Neurology·Rebecca Gilbert, Pravin Khemani
Mar 24, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Danielle S AbrahamAllison W Willis
Nov 2, 2020·International Forum of Allergy & Rhinology·Isaac A BernsteinNicholas R Rowan
May 14, 2021·Movement Disorders Clinical Practice·Paula AzevedoAlfonso Fasano
Nov 14, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Joyce W LeeJanis Miyasaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.