Frailty is independently associated with mortality in 11 001 patients with inflammatory bowel diseases

Alimentary Pharmacology & Therapeutics
Bharati D KocharAshwin N Ananthakrishnan

Abstract

The prevalence of older adults with inflammatory bowel diseases (IBD) is increasing. Frailty is an important predictor of outcomes in many chronic disease states. The implications of frailty have not been well-delineated in IBD. To report the prevalence of a frailty-associated diagnosis and determine the association between frailty and mortality in a cohort of IBD patients. In a cohort of 11 001 IBD patients, we applied a validated definition of frailty using International Classification of Disease codes. We compared frail IBD patients to those without a frailty-related code ("fit"). We constructed multivariable logistic regression models adjusting for clinically pertinent confounders (age, gender, race, IBD type, follow-up, IBD-related surgery, ≥1 comorbidity in the Charlson comorbidity index [CCI], and immunosuppression use) to determine whether frailty predicts mortality. A total of 675 (6%) IBD patients had a frailty-related diagnosis. The prevalence of frailty increased with age, rising from 4% in 20-29 year olds to 25% in patients 90 years or older. The most prevalent frailty diagnosis was protein-energy malnutrition. The strongest predictors of frailty were non-IBD comorbidity, all-cause and IBD-related, hospitalisations...Continue Reading

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Citations

Aug 28, 2020·Alimentary Pharmacology & Therapeutics·Jessica Lovatt, Christian P Selinger
Sep 19, 2020·Gastroenterology·Bharati Kochar, Ashwin N Ananthakrishnan
Mar 23, 2021·Digestive Diseases and Sciences·Simon J Hong, Seymour Katz
Apr 28, 2021·Inflammatory Bowel Diseases·Adam S Faye, Jean-Frederic Colombel
Jul 20, 2021·Therapeutic Advances in Gastroenterology·Simon J Hong, Seymour Katz
Jun 22, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Vera E R AsscherP W Jeroen Maljaars
Jan 10, 2022·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Bharati KocharOla Olén

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