Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors.

Genetics
M R CulbertsonG R Fink

Abstract

Suppressors of ICR-induced mutations that exhibit behavior similar to bacterial frameshift suppressors have been identified in the yeast Saccharomyces cerevisiae. The yeast suppressors have been divided into two groups. One of these groups (Group II: SUF1, SUF3, SUF4, SUF5 and SUF6) appears to include a set of informational suppressors in which the vehicle of suppression is glycyl-tRNA. Some of the genetic properties of Group II suppressors are described in this communication.--Corevertants of the Group II frameshift mutations his4-519 and leu2-3 have been characterized to determine the spectrum of reversion events induced by the frameshift mutagen ICR-170. Seventy-three ICR-induced corevertants were analyzed. With the exception of one cerevertant, which carried an allele of SUF1, all carried alleles of SUF3 or SUF5. SUF1, SUF3, SUF4 and SUF6 were represented among spontaneous and UV-induced corevertants. In the course of these experiments one of the suppressors was mapped. SUF5, the probable structural gene for tRNAGLY1, is located between ade2 and ade9 on chromosome XV.--SUF1, SUF4 and SUF6 have novel properties and comprise a distinct subset of suppressors. Although these suppressors show no genetic linkage to each other, th...Continue Reading

Citations

Feb 5, 2009·Nature Structural & Molecular Biology·Saverio Brogna, Jikai Wen
Apr 24, 1981·Science·T F DonahueG R Fink
Oct 28, 2009·Cellular and Molecular Life Sciences : CMLS·Pamela NicholsonOliver Mühlemann
Apr 3, 2010·The EMBO Journal·Jikai Wen, Saverio Brogna
Oct 20, 2021·PLoS Genetics·Boris ZinshteynRachel Green
Sep 15, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kouichi Ogami, Shinichi Hoshino

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