Framingham risk score and prediction of lifetime risk for coronary heart disease

The American Journal of Cardiology
Donald M Lloyd-JonesDaniel Levy

Abstract

We investigated whether the Framingham risk score, which was designed to estimate the 10-year risk of coronary heart disease (CHD), differentiates lifetime risk for CHD. All subjects in the Framingham Heart Study examined from 1971 to 1996 who were free of CHD were included. Subjects were stratified into age- and gender-specific tertiles of Framingham risk score, and lifetime risk for CHD was estimated. We followed 2,716 men and 3,500 women; 939 developed CHD and 1,363 died free of CHD. At age 40 years, in risk score tertiles 1, 2, and 3, respectively, the lifetime risks for CHD were 38.4%, 41.7%, and 50.7% for men and 12.2%, 25.4%, and 33.2% for women. At age 80 years, risks were 16.4%, 17.4%, and 38.8% for men and 12.8%, 22.4%, and 27.4% for women. The Framingham risk score stratified lifetime risk well for women at all ages. It performed less well in younger men but improved at older ages as remaining life expectancy approached 10 years. Lifetime risks contrasted sharply with shorter term risks: at age 40 years, the 10-year risks of CHD in tertiles 1, 2, and 3, respectively, were 0%, 2.2%, and 11.6% for men and 0%, 0.7%, and 2.3% for women. The Framingham 10-year CHD risk prediction model discriminated short-term risk well f...Continue Reading

Citations

Oct 12, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Mario Petretta, Alberto Cuocolo
Jul 3, 2013·Journal of Cross-cultural Gerontology·Hiram Beltrán-Sánchez, Eileen M Crimmins
Jun 9, 2009·Current Atherosclerosis Reports·David C W Lau
Dec 13, 2012·Current Atherosclerosis Reports·Daniel Steinberg
Nov 11, 2008·Clinical Reviews in Allergy & Immunology·Hasya ZingerYehuda Shoenfeld
Jul 27, 2011·European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology·Laura L HaymanLynne T Braun
Nov 26, 2010·Journal of Health Communication·Michael UssherGillian Rowlands
Feb 17, 2010·Metabolic Syndrome and Related Disorders·Dimitris M KonstantinouGeorge D Giannoglou
Mar 1, 2006·Sexually Transmitted Diseases·Roberta B NessUNKNOWN Gynecologic Infection Follow-Through, GIFT, Investigators
Aug 27, 2009·The Journal of Cardiovascular Nursing·Mary Ellen Roberts, Benjamin J Epstein
Jun 18, 2011·The Journal of Cardiovascular Nursing·Laura L HaymanLynne T Braun
Nov 11, 2006·Current Opinion in Lipidology·Donald M Lloyd-Jones
Jul 1, 2006·Journal of General Internal Medicine·David EdelmanTracy W Gaudet
Apr 15, 2006·Journal of Epidemiology and Community Health·Y G DoyleJ Flowers
Oct 22, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Ian Janssen
Feb 18, 2010·Circulation. Cardiovascular Quality and Outcomes·Judith HsiaUNKNOWN Women's Health Initiative Research Group
Jul 22, 2008·Interactive Cardiovascular and Thoracic Surgery·Laurent BarandonXavier Roques
Feb 24, 2007·Vascular Health and Risk Management·Behrouz KassaïFrançois Gueyffier
Apr 22, 2008·American Journal of Health Promotion : AJHP·Anna K I FairMark R Cobain
Oct 31, 2013·The International Journal of Cardiovascular Imaging·Kai LinJames C Carr
Nov 26, 2010·Journal of Cardiovascular Translational Research·Olivier M VandervekenPaul Van de Heyning
May 8, 2014·European Heart Journal·Hein J J WellensArthur A Wilde
Aug 6, 2010·QJM : Monthly Journal of the Association of Physicians·F D R HobbsA L Catapano
Dec 8, 2014·Journal of Molecular and Cellular Cardiology·Yi-Chu LiaoSuh-Hang H Juo
Feb 18, 2014·Journal of Clinical Lipidology·UNKNOWN Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members
Oct 9, 2015·Aging Cell·William B Zhang, Zachary Pincus
Dec 19, 2012·Journal of Pediatric Nursing·Barbara C JaquithBarbara Penprase

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