Framingham ten-year general cardiovascular disease risk: agreement between BMI-based and cholesterol-based estimates in a South Asian convenience sample

PloS One
Charlotte A JonesKarima Karmali

Abstract

The goal of this analysis was to determine the agreement between body mass index-based and cholesterol-based ten-year Framingham general cardiovascular disease risk scores among a convenience sample of 773 South Asian Canadian adults attending community-based screening clinics. Scores were calculated using age, systolic blood pressure, antihypertensive use, current smoking, diabetes, and total cholesterol and high density lipoprotein (for cholesterol-based risk) or height and weight (for body mass index-based risk). Mean risk score differences (body mass index-based risk minus cholesterol-based risk) were estimated using paired t-tests. Bland-Altman plots were used to assess agreement between scores. Finally, agreement across risk categories (low [<10%], moderate [10% to <20%], high [> = 20%]) was examined using the kappa statistic. Average agreement between the two risk scores was quite good overall (mean differences of 0.6% for men and 0.5% for women), but increased to about 3% among participants 60-74 years of age. However, Bland-Altman plots revealed that the differences between the two scores and the variability of the differences increased with increasing average 10-year risk. In terms of clinical importance, the limits o...Continue Reading

References

Jul 1, 1992·Computers in Biology and Medicine·L Cyr, K Francis
Jan 1, 1991·American Heart Journal·K M AndersonW B Kannel
Jun 6, 2003·European Heart Journal·R M ConroyUNKNOWN SCORE project group
Feb 11, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Mohsen Aarabi, Peter R Jackson
Dec 21, 2005·Heart·UNKNOWN British Cardiac SocietyUNKNOWN Stroke Association
Jan 24, 2008·Circulation·Ralph B D'AgostinoWilliam B Kannel
Jun 25, 2008·BMJ : British Medical Journal·Julia Hippisley-CoxPeter Brindle
Nov 20, 2008·Postgraduate Medical Journal·R Ramaraj, P Chellappa
May 7, 2009·Blood Pressure Monitoring·Martin G MyersAlexander Kiss
Apr 27, 2010·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Daniel W L Lai, Shireen Surood
Mar 1, 2011·Annals of Clinical Biochemistry·Anjly JainDevaki R Nair
Dec 14, 2011·International Journal of Clinical Practice·N RaoD R Nair
Dec 20, 2011·Journal of Immigrant and Minority Health·Mihir PatelCarla Boutin-Foster
Mar 20, 2012·American Journal of Preventive Medicine·Beverly B GreenRobert Reid

❮ Previous
Next ❯

Citations

Dec 21, 2018·Hypertension·Armando J Martínez-RuedaRicardo Correa-Rotter
Mar 30, 2021·International Journal of Clinical Practice·Kukulege Chamila Dinushi MettanandaArunasalam Pathmeswaran

❮ Previous
Next ❯

Methods Mentioned

BETA
blood collection

Software Mentioned

IC
QRISK2
JBS2
Stata
ETHRISK

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.