Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway

Scientific Reports
Shulan SuYuping Tang

Abstract

Frankincense and myrrh are highly effective in treatment of inflammatory diseases, but lacking of thetherapy mechanisms. We undertook this study to evaluate the effects on Adjuvant-induced Arthritis(AIA) rats and to explore the underlying mechanisms by analyzing the metabolic profiling and signalingpathway evaluated by expression of inflammatory cytokines, c-jun and c-fos and corresponding phosphorylationlevels. [corrected]. The results stated the elevated expression levels of TNFα, PGE2, IL-2, NO, and MDA in serum and swelling paw of AIA rats were significantly decreased after treatment, which exerted more remarkable inhibitive effects of combined therapy. The metbolic profiling of plasma and urine were clearly improved and twenty-one potential biomarkers were identified. Moreover, the inhibited effects of five bioactive components on cytokine transcription in PHA stimulated-PBMC showed the MAPK pathway might account for this phenomenon with considerable reduction in phosphorylated forms of all the three MAPK (ERK1/2, p38 and JNK) and down regulation of c-jun and c-fos.

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Citations

Sep 16, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tian-Yin Liu, Shi-Biao Chen
Aug 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo CaoDing-Kun Zhang
Aug 9, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yan ChenJinjun Wang
Nov 17, 2020·Dose-response : a Publication of International Hormesis Society·Somya Z MansourHebatallah E Mohamed
May 23, 2021·Scientific Reports·A H Bu-Olayan, B V Thomas

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Datasets Mentioned

BETA
NJUTCM130134

Methods Mentioned

BETA
MDA
PCA
enzyme linked immunosorbent assay
protein assay
enzyme-linked immunosorbent assay
ELISA
FCS
PCR
electrophoresis

Software Mentioned

Waters MassLynx
MetPA
OPLS
DA
MetaboAnalyst
SPSS

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