FRAXE intermediate alleles are associated with Parkinson's disease

Neuroscience Letters
Grazia AnnesiAldo Quattrone

Abstract

There is evidence that male subjects with a clinical picture of action tremor, Parkinsonism, and cerebellar ataxia may have Fragile X premutations (FRAXA). We analyzed FRAXA and FRAXE triplet repeats in 203 male subjects with Parkinson's disease (PD) and 370 healthy controls. No full mutations or premutations at the FRAXA and FRAXE loci were found in the subjects with PD or in the controls. FRAXA allele distribution was similar in patients and controls. FRAXE intermediate alleles (31-60 repeats CCG) were found in 13 of 203 (6.4%) subjects with PD and in only one of the 370 (0.27%) healthy controls (P < 0.001), thus indicating that these relatively large alleles may be associated with PD.

Citations

Mar 9, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Valentina GrecoGrazia Annesi
Jan 25, 2011·Parkinsonism & Related Disorders·Alzenira CostaElizabeth Pintado
Jul 16, 2016·The Clinical Neuropsychologist·Erin E RobertsonJoan A O'Keefe
Jul 20, 2007·Human Molecular Genetics·Oyinkan A SofolaDavid L Nelson
Sep 6, 2015·American Journal of Alzheimer's Disease and Other Dementias·Chunhong DuanZhongtao Gai
Jul 9, 2005·Current Opinion in Neurology·Yasuhiko Baba, Ryan J Uitti

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