Free and antibody-complexed antigen and antibody profile in apparently healthy HIV seropositive individuals and in AIDS patients

Journal of Medical Virology
M PorteraG Di Cuonzo

Abstract

The pattern of free and antibody-complexed HIV antigen and the antibody profile were investigated retrospectively in 305 serum samples taken from 22 AIDS patients before and during the development of AIDS and from 40 apparently healthy seropositive individuals. Most AIDS patients were found positive for both free and complexed antigen and had high gp41 antibody titres but low or undetectable p24 antibody. Four different patterns of HIV antigenaemia were observed: 1) positive for both free and complexed antigen; 2) negative for free HIV antigen at first, but always positive for complexed antigen; 3) positive for free antigen without complexed antigen; and 4) negative for both free and complexed antigen. The development of immune complexes preceded the appearance of free antigen and might reflect the ongoing viral replication with antigen excess and binding of anticore antibodies. No correlation was found between the development of AIDS symptoms and either the duration of free antigen positivity or the level of antigenaemia. A different pattern was observed in apparently healthy seropositive individuals: 90% of whom had high antibody titres to p24 and gp41 and were persistently negative for free and complexed HIV antigen. This st...Continue Reading

References

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Citations

Sep 3, 1992·The New England Journal of Medicine·P L KimmelC T Garrett
Jan 20, 2016·Nature Reviews. Nephrology·Ehsan NobakhtPaul L Kimmel
Dec 1, 1993·Kidney International·P L KimmelC T Garrett
Nov 18, 2008·Seminars in Nephrology·Scott D Cohen, Paul L Kimmel

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