Free-base nicotine in tobacco products. Part I. Determination of free-base nicotine in the particulate phase of mainstream cigarette smoke and the relevance of these findings to product design parameters

Regulatory Toxicology and Pharmacology : RTP
John H LauterbachW S Rickert

Abstract

The free-base nicotine (FBN) content of mainstream cigarette smoke (MSS) has been discussed in the peer-reviewed literature and popular press. It has been alleged that manufacturers adjust product design features to increase the percentage of total nicotine (TN) in the MSS gas-vapor phase that is unprotonated [P(g)(,nic)(%)] and/or the fraction of nicotine in the MSS total particulate matter (TPM) that is unprotonated (FBN/TN). Our research showed the Health Canada Intensive smoking conditions negated the effects of blend and cigarette design features reported to raise the pH of TPM collected under ISO or US FTC conditions. Our research also showed that when additive-free Canadian cigarettes were smoked under ISO conditions, the FBN/TN ratio increased as the tar/nicotine ratio decreased. Our findings are in line with other studies that have questioned allegations of a relationship between use of ammonia and its compounds as tobacco additives and amounts of unprotonated nicotine in MSS. In addition, the experimental work demonstrated how use of solid-phase microextraction to estimate FBN can yield erroneously high results due to improper conditioning and/or smoking of the cigarettes. Our research showed that there is no longer a...Continue Reading

References

May 1, 1991·Journal of Analytical Toxicology·Y Nakahara, A Ishigami
May 1, 1989·Journal of Analytical Toxicology·B R MartinJ P Boni
Dec 22, 1999·Journal of Agricultural and Food Chemistry·J I SeemanB E Waymack
Nov 16, 2002·Carbohydrate Research·Kwasi Agyei-AyeSerban C Moldoveanu
Aug 20, 2003·Chemical Research in Toxicology·James F PankowLorne M Isabelle
Jun 4, 2004·Tobacco Control·J E HenningfieldM Zeller
Jun 19, 2004·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jack HenningfieldBridgette Garrett
May 27, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M Kalaitzoglou, C Samara
Aug 1, 2006·Regulatory Toxicology and Pharmacology : RTP·Charlene H CallicuttJeffrey I Seeman
May 3, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jeffrey I Seeman, Richard A Carchman
Sep 11, 2008·Tobacco Control·D Hammond, R J O'Connor
Mar 17, 2009·Journal of Agricultural and Food Chemistry·Cai Chen, James F Pankow
Dec 8, 2009·Science·Katrin AdamczykErik T J Nibbering

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Citations

Dec 6, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Diana L McKinneyWilliam H Barr

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