Free Fatty Acid Increases the Expression of NLRP3-Caspase1 in Adipose Tissue Macrophages in Obese Severe Acute Pancreatitis.

Digestive Diseases and Sciences
Tao XuZhen Ding

Abstract

Obesity is an important risk factor for severe acute pancreatitis. The necrosis of epididymal adipose tissue occurs in severe acute pancreatitis. Adipose tissue macrophages play an important role in metabolic related inflammation. Therefore, we explored the potential mechanisms between adipose tissue macrophages and obesity-related severe acute pancreatitis. Severe acute pancreatitis mice model was induced by caerulein with lipopolysaccharide. The severity of severe acute pancreatitis was evaluated according to the morphological, general, and biochemical change. We assessed the injury of epididymal white adipose tissue, pancreas, and adipose tissue macrophages in obese mice and lean mice with severe acute pancreatitis. Outcomes of caerulein-induced severe acute pancreatitis were studied in lean and obese mice with or without lipase inhibitor orlistat. Fat necrosis and pancreatic injury increased in the SAP groups. High levels of serum free fatty acid and triglyceride were increased significantly in the SAP group. The NLRP3-caspase1 inflammasome signal pathway in adipose tissue macrophages markedly enhanced in the SAP groups compared with control group. Free fatty acid can trigger macrophages inflammation through NLRP3-caspase1....Continue Reading

References

Jan 1, 1992·Annals of Surgery·J SchmidtA L Warshaw
Oct 30, 2001·The Proceedings of the Nutrition Society·S W Coppack
Mar 22, 2006·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·J MartínezM Pérez-Mateo
Jan 4, 2007·The Journal of Clinical Investigation·Carey N LumengAlan R Saltiel
Mar 19, 2009·The American Journal of Gastroenterology·Wayne TsuangAndres Gelrud
Mar 11, 2010·The Journal of Pathology·Neus Franco-PonsDaniel Closa
Aug 24, 2010·World Journal of Gastroenterology : WJG·Pratima Shrivastava, Madhav Bhatia
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa Deep Dixit
May 18, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Shi-qi WangQing-chuan Zhao
Nov 4, 2011·Science Translational Medicine·Sarah NavinaVijay P Singh
Apr 10, 2012·Toxicology and Applied Pharmacology·A GammelsrudJ A Holme
May 7, 2014·Diabetes Research and Clinical Practice·Nathalie EsserNicolas Paquot
Oct 4, 2014·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Chathur AcharyaVijay P Singh
May 25, 2015·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Laia BonjochDaniel Closa
Nov 26, 2015·Frontiers in Pharmacology·Bo-Zong ShaoChong Liu
Mar 28, 2017·Journal of Cellular Physiology·Zahra HoseiniHamed Mirzaei
Jun 24, 2017·Metabolism: Clinical and Experimental·Dylan Thomas, Caroline Apovian
Jul 19, 2017·Current Opinion in Gastroenterology·Biswajit KhatuaVijay P Singh
Aug 23, 2017·Annual Review of Nutrition·Jessica C RalstonHelen M Roche
Apr 11, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rasheed AhmadEvan D Rosen
Jul 22, 2018·Nature Reviews. Drug Discovery·Matthew S J ManganEicke Latz
Sep 20, 2018·Immunology·Lucia Russo, Carey N Lumeng
Feb 16, 2019·Gastroenterology·Pramod K Garg, Vijay P Singh
Apr 5, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yanyan QiYuanyuan Zhao
Nov 11, 2019·Life Sciences·Jun-Hui XingLing Li
Jan 10, 2020·The Journal of Clinical Investigation·Cristiane de OliveiraVijay P Singh
Apr 3, 2020·Immunological Reviews·Heather L CaslinAlyssa H Hasty
Dec 20, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Pandian NagakannanEftekhar Eftekharpour

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