PMID: 6971806Mar 1, 1981Paper

Free fatty acidemia as an inducer of systemic hyperfibrinogenemia and fibrinolytic inhibition

Inflammation
L Pickart

Abstract

Many major inflammatory stimuli induce secondary conditions of blood hyperfibrinogenemia and fibrinolytic inhibition, changes which may be mediated by alterations in free fatty acid (FFA) metabolism. The effect of a free fatty acidemia induced by the intravenous infusion of a triglyceride into rabbits on the fibrinogen/fibrinolytic system was determined. A 3-h infusion of synthetic fat emulsion induced a rapid rise in FFA (0.4-2.1 microEq/ml in 3 h) followed by a more gradual rise in fibrinogen (2.6-4.3 mg/ml at 24 h), alpha 1-antitrypsin (1.1-1.9 mg/ml at 48 h), and serum fibrinolysis inhibitory activity (increased 202% at 48 h). Increases in protein concentration were due to increased synthesis. It is proposed that the changes in the fibrinogen/fibrinolytic system which follow major inflammatory stimuli are induced by a mediating free fatty acidemia. Possible pharmacological procedures to block these changes are discussed.

References

Mar 1, 1978·The Biochemical Journal·A KojE Regoeczi
Jan 1, 1979·Thrombosis Research·L Pickart, M M Thaler
Mar 1, 1976·Microvascular Research·T Saldeen
Apr 1, 1976·The American Journal of Physiology·L R Pickart, M M Thaler
Apr 1, 1969·The American Journal of Physiology·A C AtencioE B Reeve
Aug 1, 1969·Experimental and Molecular Pathology·H C Kwaan, T Astrup
Mar 1, 1961·The Journal of Experimental Medicine·J W FARQUHARM SOKOLOW

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Citations

Jul 1, 1997·Thrombosis Research·D A Handley, T E Hughes
Feb 28, 1981·Lancet·A W Burrows, D Barnett
Apr 1, 1996·Medical Hypotheses·M F McCarty
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Prabhakaran BalagopalNelly Mauras
Jan 1, 1996·Platelets·D P Mikhailidis, E S Ganotakis
Jun 7, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ernst-Joachim FreyseWerner Siegmund
Jul 20, 2001·Annals of the New York Academy of Sciences·M P de Maat
Mar 1, 1995·Medical Hypotheses·M F McCarty

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