Free fatty acids increase hepatic glycogen content in obese males

Metabolism: Clinical and Experimental
G AllickH P Sauerwein

Abstract

Obesity is associated with increased hepatic glycogen content. In vivo and in vitro data suggest that plasma free fatty acids (FFA) may cause this increase. In this study we investigated the effect of physiological plasma FFA levels on hepatic glycogen metabolism by studying intrahepatic glucose pathways in lean and obese subjects. Six lean and 6 obese males were studied twice during a 16- to 22-hour fast, once with and once without acipimox, an inhibitor of lipolysis. Intrahepatic glucose fluxes were measured by infusion of [2-(13C1)]glycerol, [1-(2H1)]galactose, and [U-(13C6)]glucose. Acetaminophen was administered as a glucuronate probe. In both lean and obese control studies, plasma FFA levels increased progressively, whereas acipimox completely suppressed plasma FFA levels for the whole study period. In lean males glycogenolysis did not change in the acipimox study, but decreased in the control study (P < .01). In lean males, neither glycogen synthesis, glycogen synthesis retained as glycogen, nor glycogen balance differed between control and acipimox studies. In obese males glycogenolysis did not change in the acipimox study, but decreased in the control study (P < .01). Glycogen synthesis did not change in either study. ...Continue Reading

References

Sep 1, 1997·The Journal of Clinical Investigation·M K HellersteinA Letscher
Feb 24, 1998·Metabolism: Clinical and Experimental·R L DobbinsA D Cherrington
Jul 10, 1998·Annals of Nutrition & Metabolism·I LladóA Pons
Feb 2, 1999·The Journal of Clinical Investigation·X ChenG Boden
Oct 21, 2000·European Journal of Clinical Nutrition·D Elahi, D C Muller
Jun 19, 2002·Journal of Applied Physiology·Jeff K TrimmerGeorge A Brooks
Apr 5, 2003·American Journal of Physiology. Endocrinology and Metabolism·Tony K T LamAdria Giacca

Related Concepts

Nedios
Antilipemic agent
C-Peptide
Fasting
Nonesterified Fatty Acids
Gluconeogenesis
Anhydrous Dextrose
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Insulin B Chain
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