Free radical formation by antitumor quinones

Free Radical Biology & Medicine
G Powis

Abstract

Quinones are among the most frequently used drugs to treat human cancer. All of the antitumor quinones can undergo reversible enzymatic reduction and oxidation, and form semiquinone and oxygen radicals. For several antitumor quinones enzymatic reduction also leads to formation of alkylating species but whether this involves reduction to the semiquinone or the hydroquinone is not always clear. The antitumor activity of quinones is frequently linked to DNA damage caused by alkylating species or oxygen radicals. Some other effects of the antitumor quinones, such as cardiotoxicity and skin toxicity, may also be related to oxygen radical formation. The evidence for a relationship between radical formation and the biological activity of the antitumor quinones is evaluated.

References

Jul 25, 1977·Biochemical and Biophysical Research Communications·J Goodman, P Hochstein
Feb 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·N R BachurH Kon
Aug 1, 1976·Archives of Biochemistry and Biophysics·F J Yost, I Fridovich
Jun 6, 1977·Biochemical and Biophysical Research Communications·J W LownR Y Chang
Dec 1, 1977·Chemico-biological Interactions·W S Thayer
Nov 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M GosálvezF Vallés
Sep 1, 1979·Journal of Medicinal Chemistry·B K SinhaR L Cysyk
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K FolkersA B Combs
Jan 1, 1979·Cytogenetics and Cell Genetics·T B Shows, P J McAlpine
Jan 1, 1978·Antibiotics and Chemotherapy·G ZbindenC Holderegger
Jan 26, 1979·Biochimica Et Biophysica Acta·A J FornaceR R Weichselbaum
Jan 1, 1979·Journal of Medicinal Chemistry·G L TongE M Acton
Jun 15, 1979·Toxicology and Applied Pharmacology·E G MimnaughT E Gram
Sep 1, 1979·Journal of Medicinal Chemistry·K C MurdockR V Citarella
Nov 1, 1979·Annals of Internal Medicine·D D Von HoffF M Muggia
Aug 1, 1979·The Journal of Antibiotics·A Someya, N Tanaka
Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·J W Harris, D C Shrieve
Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·W M Martin, N J McNally
Dec 1, 1979·Chemico-biological Interactions·B K Sinha, C F Chignell
Oct 15, 1978·FEBS Letters·C C WinterbournR F Claridge
Dec 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H CortésM Gosálvez
Jan 1, 1978·American Journal of Hematology·M J StuartM K Barvinchak
Apr 1, 1976·Chemico-biological Interactions·M Tomasz
Jan 31, 1976·Molecular and Cellular Biochemistry·A BozziG Rotilio
Apr 1, 1977·Journal of the National Cancer Institute·S K SahuE F Riley
Jun 1, 1977·The Journal of Antibiotics·D E NettletonA L Vulcano
Nov 1, 1976·Journal of Medicinal Chemistry·F ChouJ S Driscoll
Oct 1, 1975·The Journal of Antibiotics·T OkiI Kitamura
Feb 1, 1976·Journal of Medicinal Chemistry·A H Khan, J S Driscoll
Mar 1, 1976·Canadian Journal of Biochemistry·R ConeA R Morgan
Jan 1, 1985·Investigational New Drugs·R J White, F E Durr
Jan 1, 1986·Biochemical Pharmacology·H Wefers, H Sies
Jan 1, 1986·Biochemical Pharmacology·A C Sartorelli
Jan 1, 1985·Journal of Toxicology and Environmental Health·M S BergerM T Smith
Apr 1, 1986·Biochemical Pharmacology·M G MillerG M Cohen

❮ Previous
Next ❯

Citations

Jun 9, 1998·Journal of Cellular Physiology·M P NambiarH C Wu
Aug 30, 2000·International Journal of Cancer. Journal International Du Cancer·K KahlosV L Kinnula
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Misako ShibakuraMitsune Tanimoto
Aug 24, 2001·International Journal of Cancer. Journal International Du Cancer·T KiguchiM Harada
Apr 1, 1990·Journal of Applied Toxicology : JAT·E Kruger-ZeitzerR Munday
Apr 1, 1991·Journal of Applied Toxicology : JAT·R MundayE A Fowke
Sep 1, 1991·Journal of Cellular Physiology·M Buchwald, C Clarke
Jun 1, 1993·Cancer Metastasis Reviews·A M RauthB L Kuehl
Jan 1, 1993·Cytotechnology·J DoehmerN P Vermeulen
Jan 1, 1995·Biological Trace Element Research·H HidaA Favier
Jul 13, 2005·Cancer Chemotherapy and Pharmacology·Brian B HasinoffJack C Yalowich
Jan 27, 2007·Cancer Chemotherapy and Pharmacology·Asher BegleiterBrian B Hasinoff
Aug 15, 1989·Archives of Biochemistry and Biophysics·F A RedegeldJ Noordhoek
Nov 3, 1992·Biochemical Pharmacology·A J KettleC C Winterbourn
Jan 1, 1991·Chemico-biological Interactions·P J O'Brien
Jul 16, 1994·Mutation Research·R J BrennanR H Schiestl
Jan 1, 1994·Pharmacology & Therapeutics·M E GötzM B Youdim
Jan 27, 1995·Cancer Letters·Y S Lee, R D Wurster
Dec 1, 1994·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A R ParrishK Brendel
Jan 1, 1990·Free Radical Biology & Medicine·R E Beyer
Dec 1, 1992·Free Radical Biology & Medicine·K J LusthofD N Reinhoudt
Apr 1, 1995·Free Radical Biology & Medicine·P MuñizG T Sáez
Jun 1, 1995·Free Radical Biology & Medicine·D E ThorntonD G Cornwell
Nov 1, 1995·Free Radical Biology & Medicine·K Ollinger, U T Brunk
Dec 1, 1995·Free Radical Biology & Medicine·R MundayC M Munday
Jan 1, 1996·Free Radical Biology & Medicine·O I Aruoma
May 25, 2005·Biochemical and Biophysical Research Communications·Takaaki OtekiAkio Koyama
Jan 23, 2002·Chemico-biological Interactions·Lorenzo LusiniPaolo Di Simplicio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.