Jan 1, 1980

Free radical initiation in proteins and amino acids by ionizing and ultraviolet radiations and lipid oxidation--part III: free radical transfer from oxidizing lipids

Critical Reviews in Food Science and Nutrition
K Schaich

Abstract

Parallels and similarities in chemical and functional damage to proteins by ionizing and uv radiations and oxidizing lipids have been recognized for some time. However, only recently have oxidizing lipids been shown directly by electron spin resonance to be radiomimetic also in their capacity for protein free radical production. Free radicals play a key role in the transformation of energy to molecular and cellular damage. It is thus of critical importance to elucidate the general mechanisms of free radical formation and reactions in proteins in order to understand protein involvement in various pathological conditions and in food deterioration. Accordingly, this review is a detailed comparison of gamma-radiation, UV radiation, and lipid oxidation for what is presently known concerning (1) the specific modes of energy deposition and free radical formation, (2) the free radicals formed in proteins and amino acids, and (3) the typical damage correlating with these radicals.

  • References187
  • Citations18

References

Mentioned in this Paper

Energy Transfer
Cell Injury
Food
Gene Products, Protein
Free Radicals
Lipid Peroxides
Nutrients
Radicals (chemistry)
Response to Gamma Radiation
oxidized lipid

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