Free radical production in the esophago-gastro-duodenal mucosa in response to acid and bile

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
L BoniA Cuschieri

Abstract

Several studies have demonstrated the role of free radicals in causing esophagus-gastro-duodenal mucosal injury. The present study has been designed to investigate: whether acid, bile salts and a combination of bile + acid could determine the production of O2-derived free radicals by oesophageal, gastric and duodenal mucosa; which agent is capable of producing more free radicals and if O2-derived free radicals production depends on the duration of contact with acid, bile salts and their combination. Wistar rats' gastro-intestinal mucosa were perfused with bile, acid and a combination of bile + acid at pH4 and pH2 for 1 hour and 2 hours. Free radical production (FRP) was assessed by chemoluminescence. After 1 hour, the increase in FRP in comparison with control reached statistical significance (P < 0.05) at all tested pH levels in the duodenum, at pH1, 2 and 3 in the esophagus, and at pH1 in the stomach. Comparing different segments, both the esophagus and duodenum behaved similarly, producing more free radicals than the stomach at all pH values. However, this difference reached statistical significance at pH1 and 2 only. In comparison to control, FRP was increased by bile (pH7) infusion after 1 and 2 hours. There was increased ...Continue Reading

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Citations

Apr 24, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Marcelo BinatoMaria Isabel Edelweiss
Apr 4, 2015·World Journal of Gastroenterology : WJG·Maria Coats, Sami M Shimi

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