Free-radical scavenger edaravone inhibits both formation and development of abdominal aortic aneurysm in rats

Journal of Vascular Surgery
Keisuke MorimotoKenji Okada

Abstract

An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to prevent aneurysm formation and development (further dilatation of pre-existing aneurysm). Recent studies have reported that oxidative stress with reactive oxygen species (ROS) is crucial in aneurysm formation. We hypothesized that edaravone, a free-radical scavenger, would attenuate vascular oxidative stress and inhibit AAA formation and development. An AAA model induced with intraluminal elastase and extraluminal calcium chloride was created in 42 rats. Thirty-six rats were divided three groups: a low-dose (group LD; 1 mg/kg/d), high-dose (group HD; 5 mg/kg/d), and control (group C, saline). Edaravone or saline was intraperitoneally injected twice daily, starting 30 minutes before aneurysm preparation. The remaining six rats (group DA) received a delayed edaravone injection (5 mg/kg/d) intraperitoneally, starting 7 days after aneurysm preparation to 28 days. AAA dilatation ratio was calculated. Pathologic examination was performed. ROS expression was semi-quantified by dihydroethidium staining and the oxidative product of DNA induced by ROS, 8-hydroxydeoxyguanosine (8-OHdG), by immunohistochemical staining. At day 7, ROS expression and 8-OHdG-positive ...Continue Reading

References

Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·H NishiA Ishibashi
Jan 1, 1986·Free Radical Research Communications·R A FloydR C Rickard
Jul 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T WatanabeS Murota
Mar 1, 1996·The British Journal of Surgery·H S KhairaC P Shearman
Mar 10, 1997·FEBS Letters·P F LiR von Harsdorf
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Sep 5, 2002·The Journal of Clinical Investigation·G Matthew LongoB Timothy Baxter
Sep 17, 2002·European Journal of Pharmacology·Kunihiko SueishiRyozo Oishi
Sep 6, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Ronald L Dalman
Aug 18, 2005·Clinical Science·Robin Ray, Ajay M Shah
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Kazuchika SuzukiJunji Yasuike
Nov 29, 2005·Nature Medicine·Koichi YoshimuraMasunori Matsuzaki
Nov 13, 2007·Auris, Nasus, Larynx·Taizo TakedaKazuhiro Yamakawa
May 27, 2008·Atherosclerosis·Wanfen XiongJason Johanning
Aug 8, 2008·Annals of Vascular Surgery·Makoto HamaishiTaijiro Sueda
Feb 12, 2011·Investigative Ophthalmology & Visual Science·Mi In RohJoan W Miller

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Citations

Aug 21, 2013·Cardiovascular Research·Sandrine DelboscOlivier Meilhac
Oct 10, 2012·Atherosclerosis·Yutang WangJonathan Golledge
Jul 10, 2016·The Journal of Surgical Research·Li TangHua Jing
Aug 1, 2015·Perfusion·Umit MenteşeAhmet Çağrı Aykan
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Wei-Wei LuYong-Fen Qi
Sep 5, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Kuan-Chieh WangHua-Lin Wu
Feb 15, 2019·Circulation Research·Jan H Lindeman, Jon S Matsumura
Jan 28, 2016·Clinical Science·Theophilus I EmetoJonathan Golledge
Apr 16, 2021·Journal of Medicinal Chemistry·Elisa SassettiLuca Laraia
Feb 9, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Chao-Han LaiTsung-Lin Cheng
May 10, 2017·Journal of Vascular Surgery·Gözde TekinAdnan Çobanoğlu

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