Abstract
An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to prevent aneurysm formation and development (further dilatation of pre-existing aneurysm). Recent studies have reported that oxidative stress with reactive oxygen species (ROS) is crucial in aneurysm formation. We hypothesized that edaravone, a free-radical scavenger, would attenuate vascular oxidative stress and inhibit AAA formation and development. An AAA model induced with intraluminal elastase and extraluminal calcium chloride was created in 42 rats. Thirty-six rats were divided three groups: a low-dose (group LD; 1 mg/kg/d), high-dose (group HD; 5 mg/kg/d), and control (group C, saline). Edaravone or saline was intraperitoneally injected twice daily, starting 30 minutes before aneurysm preparation. The remaining six rats (group DA) received a delayed edaravone injection (5 mg/kg/d) intraperitoneally, starting 7 days after aneurysm preparation to 28 days. AAA dilatation ratio was calculated. Pathologic examination was performed. ROS expression was semi-quantified by dihydroethidium staining and the oxidative product of DNA induced by ROS, 8-hydroxydeoxyguanosine (8-OHdG), by immunohistochemical staining. At day 7, ROS expression and 8-OHdG-positive ...Continue Reading
References
Sep 1, 1989·Stroke; a Journal of Cerebral Circulation·H NishiA Ishibashi
Jan 1, 1986·Free Radical Research Communications·R A FloydR C Rickard
Jul 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T WatanabeS Murota
Mar 1, 1996·The British Journal of Surgery·H S KhairaC P Shearman
Dec 1, 1996·The Journal of Clinical Investigation·S RajagopalanZ S Galis
Mar 10, 1997·FEBS Letters·P F LiR von Harsdorf
Jul 2, 1998·Circulation Research·F J MillerB L Davidson
Mar 17, 2000·Circulation Research·K K GriendlingM Ushio-Fukai
Jun 7, 2000·The Journal of Clinical Investigation·R PyoR W Thompson
Aug 10, 2002·Journal of Vascular Surgery·Noriyuki YajimaJohn Y-J Shyy
Sep 5, 2002·The Journal of Clinical Investigation·G Matthew LongoB Timothy Baxter
Sep 17, 2002·European Journal of Pharmacology·Kunihiko SueishiRyozo Oishi
Apr 29, 2003·Cerebrovascular Diseases·UNKNOWN Edaravone Acute Infarction Study Group
Aug 2, 2003·Journal of Vascular Surgery·Jian ZhangJens Rainer Allenberg
Sep 6, 2003·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Ronald L Dalman
Oct 14, 2003·Cardiovascular Research·Junya EjiriMitsuhiro Yokoyama
Aug 18, 2005·Clinical Science·Robin Ray, Ajay M Shah
Nov 26, 2005·The Journal of Thoracic and Cardiovascular Surgery·Kazuchika SuzukiJunji Yasuike
Nov 29, 2005·Nature Medicine·Koichi YoshimuraMasunori Matsuzaki
Jun 30, 2006·Atherosclerosis·Hang XiKenji Toba
Jul 13, 2006·CNS Drug Reviews·Hiroshi YoshidaNorio Tada
Jul 26, 2006·Circulation·Manesh ThomasNeal L Weintraub
Nov 13, 2007·Auris, Nasus, Larynx·Taizo TakedaKazuhiro Yamakawa
May 27, 2008·Atherosclerosis·Wanfen XiongJason Johanning
Aug 8, 2008·Annals of Vascular Surgery·Makoto HamaishiTaijiro Sueda
Dec 5, 2009·Journal of Vascular Surgery·Akiko TanakaKenji Okada
Feb 12, 2011·Investigative Ophthalmology & Visual Science·Mi In RohJoan W Miller
Citations
Aug 21, 2013·Cardiovascular Research·Sandrine DelboscOlivier Meilhac
Apr 20, 2014·PloS One·Fanny HuyardAnne Monique Nuyt
Apr 17, 2016·Carbohydrate Polymers·Irina Yu Ponedel'kinaVictor N Odinokov
Jun 25, 2013·Journal of Vascular Surgery·Wulan BaoKenji Okada
Dec 15, 2015·Surgery Today·Jie YuKenji Okada
Feb 4, 2014·The Journal of Surgical Research·Tao ShangChang-jian Liu
Oct 10, 2012·Atherosclerosis·Yutang WangJonathan Golledge
Jun 14, 2015·Journal of Vascular Surgery·Zhenhai YuKenji Okada
Jul 10, 2016·The Journal of Surgical Research·Li TangHua Jing
Jul 31, 2016·Journal of Vascular Surgery·Shuji SetozakiRyuzo Sakata
Apr 29, 2016·PloS One·Kathleen ChinR Ann Word
Aug 1, 2015·Perfusion·Umit MenteşeAhmet Çağrı Aykan
Mar 9, 2018·Annals of Vascular Diseases·Mitsuhiro YamamuraMasaaki Ryomoto
Oct 28, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Wei-Wei LuYong-Fen Qi
Sep 5, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Kuan-Chieh WangHua-Lin Wu
Feb 15, 2019·Circulation Research·Jan H Lindeman, Jon S Matsumura
Jun 30, 2018·International Journal of Molecular Medicine·Junlu PengPeng Liu
Jan 28, 2016·Clinical Science·Theophilus I EmetoJonathan Golledge
Sep 19, 2018·International Journal of Molecular Medicine·Juntao HuQianxue Chen
Sep 25, 2020·Antioxidants·Lara T MeitalFraser D Russell
Jan 1, 2013·Molecular and Cellular Biochemistry·Hao ZhangZhi-Peng Hu
Apr 16, 2021·Journal of Medicinal Chemistry·Elisa SassettiLuca Laraia
Feb 9, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Chao-Han LaiTsung-Lin Cheng
Sep 3, 2021·Biological & Pharmaceutical Bulletin·Renfeng QiuXuejun Wu
May 10, 2017·Journal of Vascular Surgery·Gözde TekinAdnan Çobanoğlu