PMID: 8971349Oct 1, 1996Paper

Free radical scavengers suppress the accumulation of platinum in the cerebral cortex

Biological Trace Element Research
T MinamiY Okazaki

Abstract

We investigated whether free radical scavengers and antioxidants inhibit the accumulation of platinum (Pt) in the cerebral cortex. Pt was detected in the cerebral cortex of mice after administration of cisplatin and exposure to short-term hypoxia. When mice were treated with either allopurinol (20 mg/kg) or catalase (100 mg/kg) before cisplatin administration and low oxygen exposure, Pt was not detected in the cerebral cortex. However, Pt was detected in the cerebral cortex of mice pretreated with either a low dosage of allopurinol or heat-denatured catalase. Furthermore, Pt was detected in the cerebral cortex of mice preadministered vitamin C, vitamin E, or deferoxamine. Lipid peroxide levels in the cerebral cortex increased 10 min after the treatment of hypoxia, and peaked 30 min after the treatment. These results suggested that short-term hypoxia produces free radicals, which allows Pt to pass through the blood-brain barrier and accumulate in the cerebral cortex, and that the production of free radicals is reduced by the administration of either allopurinol or catalase, which prevents Pt from passing through the barrier.

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Citations

Jan 28, 2004·European Journal of Pharmacology·Sachiko TanihataToshimitsu Uchiyama
Dec 29, 1998·Toxicology·T MinamiY Okazaki
Jan 1, 2013·Journal of Otology·Ding DalianMasaru Tanokura
Sep 23, 2000·Anti-cancer Drugs·B OlasA Buczyński
Jun 29, 2021·Frontiers in Molecular Biosciences·Maryam OmranIan R Kleckner

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