Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods

Pharmaceutical Biology
Werayut PothitiratWandee Gritsanapan

Abstract

The ethanol extracts of mangosteen fruit rinds prepared by several extraction methods were examined for their contents of bioactive compounds, DPPH-scavenging activity, and anti-acne producing bacteria against Propionibacterium acnes and Staphylococcus epidermidis. The dried powder of the fruit rind was extracted with 95% ethanol by maceration, percolation, Soxhlet extraction, ultrasonic extraction, and extraction using a magnetic stirrer. Soxhlet extraction promoted the maximum contents of crude extract (26.60% dry weight) and alpha-mangostin (13.51%, w/w of crude extract), and also gave the highest anti-acne activity with MIC 7.81 and 15.63 microg/mL and MBC 15.53 and 31.25 microg/mL against P. acnes and S. epidermidis, respectively. Ethanol 70% and 50% (v/v) were also compared in Soxhlet extraction. Ethanol 50% promoted the extract with maximum amounts of total phenolic compounds (26.96 g gallic acid equivalents/100 g extract) and total tannins (46.83 g tannic acid equivalents/100 g extract), and also exhibited the most effective DPPH-scavenging activity (EC(50) 12.84 microg/mL). Considering various factors involved in the process, Soxhlet extraction carried a low cost in terms of reagents and extraction time. It appears to ...Continue Reading

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Citations

May 25, 2012·Journal of Natural Medicines·Nuttavut KosemPrimchanien Moongkarndi
Feb 24, 2016·International Journal of Molecular Sciences·Magdalena DziałoAnna Kulma
Oct 12, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Azila Abdul Karim, Azrina Azlan
Jul 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ali GhasemzadehAmin Tayebi-Meigooni
Nov 14, 2018·Immunopharmacology and Immunotoxicology·Nuo XuZhenlin Hu
May 18, 2017·International Journal of Molecular Sciences·Ashley K ClarkRaja K Sivamani
Oct 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Juanmei ZhangGang Wang
Jan 12, 2021·Frontiers in Pharmacology·Natalie Vivien GunterSiau Hui Mah

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