Free radicals and muscle fatigue: Of ROS, canaries, and the IOC

Free Radical Biology & Medicine
Michael B Reid

Abstract

Skeletal muscle fibers continually generate reactive oxygen species (ROS) at a slow rate that increases during muscle contraction. This activity-dependent increase in ROS production contributes to fatigue of skeletal muscle during strenuous exercise. Existing data suggest that muscle-derived ROS primarily act on myofibrillar proteins to inhibit calcium sensitivity and depress force. Decrements in calcium sensitivity and force are acutely reversible by dithiothreitol, a thiol-selective reducing agent. These observations suggest that thiol modifications on one or more regulatory proteins are responsible for oxidant-induced losses during fatigue. More intense ROS exposure leads to losses in calcium regulation that mimic pathologic changes and are not reversible. Studies in humans, quadrupeds, and isolated muscle preparations indicate that antioxidant pretreatment can delay muscle fatigue. In humans, this phenomenon is best defined for N-acetylcysteine (NAC), a reduced thiol donor that supports glutathione resynthesis. NAC has been shown to inhibit fatigue in healthy adults during electrical muscle activation, inspiratory resistive loading, handgrip exercise, and intense cycling. These findings identify ROS as endogenous mediators ...Continue Reading

References

Aug 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·C S Roussos, P T Macklem
Nov 1, 1992·Journal of Applied Physiology·M B ReidM L Entman
Nov 1, 1992·Journal of Applied Physiology·M B ReidM S West
Nov 21, 1992·Annals of the New York Academy of Sciences·F B PruijnH Joenje
Nov 15, 1991·Klinische Wochenschrift·R Ruffmann, A Wendel
Oct 1, 1990·Archives of Biochemistry and Biophysics·G G DuthieP C Morrice
Mar 1, 1990·The Biochemical Journal·D F LiuA Stracher
Jan 1, 1990·Free Radical Biology & Medicine·G P NovelliS Falsini
May 1, 1990·Journal of Applied Physiology·C ShindohG Supinski
Jan 1, 1989·The International Journal of Biochemistry·S SumidaF Nakadomo
Jan 1, 1989·European Journal of Clinical Pharmacology·L F PrescottA T Proudfoot
Apr 1, 1989·Journal of Bioenergetics and Biomembranes·J J Abramson, G Salama
Nov 20, 1985·Biochimica Et Biophysica Acta·M J JacksonM C Symons
Jan 1, 1988·European Journal of Clinical Pharmacology·B OlssonP Bolme
Jan 1, 1986·European Journal of Clinical Pharmacology·L BorgströmO Paulsen
Apr 1, 1984·Journal of Muscle Research and Cell Motility·M S Crowder, R Cooke
Jul 28, 1984·British Medical Journal·T G MantJ C Talbot
Aug 31, 1982·Biochemical and Biophysical Research Communications·K J DaviesL Packer
Nov 1, 1994·Journal of Applied Physiology·P T DiazT L Clanton
Jul 1, 1994·Journal of Applied Physiology·F A Khawli, M B Reid
Dec 1, 1994·Archives of Biochemistry and Biophysics·C D PhungJ F Turrens
Dec 1, 1994·The Journal of Clinical Investigation·M B ReidA A Leis
Feb 1, 1993·Medicine and Science in Sports and Exercise·H M Alessio
Sep 1, 1995·Journal of Applied Physiology·C K Sen
Sep 1, 1996·Journal of Applied Physiology·C A O'NeillJ C Longhurst
Oct 1, 1996·The European Respiratory Journal·G StassijnsM Decramer
Jan 1, 1997·Free Radical Biology & Medicine·A HasegawaT Okubo
Jan 1, 1997·Experimental Physiology·M AlbertiniG Aguggini
Feb 1, 1997·American Journal of Respiratory and Critical Care Medicine·G SupinskiA DiMarco
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·R C KolbeckT M Nosek
Jun 1, 1997·Journal of Sports Sciences·L Packer
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·J M TravalineG J Criner
Jan 1, 1997·Free Radical Biology & Medicine·N KozlovskyN Bashan
Apr 4, 1998·Medicine and Science in Sports and Exercise·P T DiazT L Clanton
May 8, 1998·The Proceedings of the Nutrition Society·M Kanter
Feb 27, 1999·Cellular Signalling·T ChakrabortiS Chakraborti
Jun 9, 1999·Mechanisms of Ageing and Development·C SchöneichD J Bigelow
Jun 11, 1999·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·A H Goldfarb

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Citations

Sep 25, 2010·Current Hypertension Reports·Marina Bayeva, Hossein Ardehali
Aug 13, 2011·Journal of Sports Sciences·Scott PowersEnette Larson-Meyer
Mar 8, 2011·Antioxidants & Redox Signaling·Håkan Westerblad, David G Allen
Feb 9, 2010·Journal of Medicinal Food·Xin FuJorgen Dam
May 29, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michael J RyanStephen E Alway
Mar 19, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Satoshi HaramizuTakatoshi Murase
Nov 15, 2011·Critical Care Medicine·Ashley J SmuderScott K Powers
Jun 26, 2010·Exercise and Sport Sciences Reviews·Edward M Balog
Dec 21, 2011·Exercise and Sport Sciences Reviews·Troy L Merry, Glenn K McConell
Feb 24, 2009·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Luciano A da SilvaRicardo A Pinho
Oct 22, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Howard J GreenSusan Tupling
Mar 6, 2010·Journal of Applied Physiology·Melissa A WhiddenScott K Powers
Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
Jul 29, 2009·American Journal of Respiratory Cell and Molecular Biology·J Richard SkellyKen D O'Halloran
Jan 1, 2013·BMC Veterinary Research·Wendy I BaltzerErica C McKenzie
Apr 21, 2012·Pakistan Journal of Biological Sciences : PJBS·Madiha Zamin
Aug 27, 2013·Antioxidants & Redox Signaling·Christopher W WardW Jonathan Lederer
Aug 6, 2013·Pflügers Archiv : European journal of physiology·Abram KatzHåkan Westerblad
May 27, 2014·Journal of the International Society of Sports Nutrition·Muqing YiC-Y Oliver Chen
May 17, 2011·European Journal of Applied Physiology·Ricardo A PinhoClaudio T Souza
Nov 4, 2010·European Journal of Nutrition·Fabiano Kenji HaraguchiMaria Lúcia Pedrosa
Apr 5, 2012·Canadian Journal of Physiology and Pharmacology·Howard J GreenSusan Tupling
Jan 10, 2016·Redox Biology·Alex J WadleySteven J Coles
Aug 25, 2015·Molecular Medicine Reports·Nikolaos GoutzourelasDemetrios Kouretas
Feb 9, 2016·Free Radical Biology & Medicine·G L CloseJ P Morton
Feb 26, 2016·Free Radical Biology & Medicine·Shaun A MasonGlenn D Wadley
Dec 25, 2012·Mechanisms of Ageing and Development·Oren RomAbraham Z Reznick
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Robert A Frost, Charles H Lang
Dec 21, 2010·Free Radical Biology & Medicine·Scott K PowersMatthew B Hudson

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