Apr 18, 2017

Free radicals and polyphenols: The redox chemistry of neurodegenerative diseases

European Journal of Medicinal Chemistry
Sonia Losada-Barreiro, Carlos Bravo-Díaz

Abstract

The oxidation of bioorganic materials by air and, particularly, the oxidative stress involved in the cell loss and other pathologies associated with neurodegenerative diseases (NDs) are of enormous social and economic importance. NDs generally involve free radical reactions, beginning with the formation of an initiating radical by some redox, thermal or photochemical process, causing nucleic acid, protein and lipid oxidations and the production of harmful oxidative products. Physically, persons afflicted by NDs suffer progressive loss of memory and thinking ability, mood swings, personality changes, and loss of independence. Therefore, the development of antioxidant strategies to retard or minimize the oxidative degradation of bioorganic materials has been, and still is, of paramount importance. While we are aware of the importance of investigating the biological and medical aspects of the diseases, elucidation of the associated chemistry is crucial to understanding their progression, heading to intelligent chemical intervention to find more efficient therapies to prevent or delay the onset of the diseases. Accordingly, this review aims to provide the reader with a chemical base to understand the behavior and properties of the ...Continue Reading

  • References22
  • Citations12

References

Mentioned in this Paper

Tocopherol
C1S
Metabolic Process, Cellular
Biological Membrane
Biochemical Pathway
Alcohols
Peroxyl
Memory Loss
Semiquinone
Exertion

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