Free radicals in blood: evolving concepts in the mechanism of ischemic heart disease

Archives of Biochemistry and Biophysics
M M Elahi, Bashir M Matata

Abstract

There has been a considerable debate over past decade on how reactive oxidant species (ROS) in blood augment the cell signaling processes involved in the pathogenesis of coronary heart disease. In particular, it is not clear whether ROS is an important component of the cross-talk between blood and elements of the vasculature during the initial and latter stages of vascular injury and development of atherosclerotic lesions. Features like the recruitment of the circulating activated monocytes, T cells and granulocytes occur extensively in patients with acute coronary syndromes. It is not known what drives the infiltration of these cells into the vessel wall in the active stages of atherosclerosis and whether ROS plays an intermediate part. Currently, the thinking is that although inflammatory processes may be prompted by different etiological factors from that of coronary heart disease, the presence of ROS in circulating blood is the key intermediary related to vascular injury and organ dysfunction. We review, the clinical and experimental data of the mechanisms involved, and evaluate the wider implications of this concept.

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Citations

Jun 25, 2008·The British Journal of Nutrition·Siegfried KnasmüllerKarl-Heinz Wagner
Dec 1, 2009·The British Journal of Nutrition·Cheng-Jeng TaiHong-Jen Liang
Aug 23, 2011·Therapeutic Advances in Chronic Disease·Julie A WolframHyoung-Gon Lee
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Maqsood M ElahiBashir M Matata
Aug 29, 2009·Biochimica Et Biophysica Acta·Marjolaine RocheOlivier Dangles
Sep 2, 2008·Archives of Medical Research·Irina V GorudkoAlexander V Timoshenko
May 28, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Maqsood M ElahiBashir M Matata
Jun 2, 2015·Canadian Journal of Physiology and Pharmacology·Jan SlezakMiroslav Barancik
Sep 23, 2008·Biochemical and Biophysical Research Communications·Maqsood M Elahi, Bashir M Matata
Oct 1, 2007·Therapeutic Advances in Respiratory Disease·Ján TkácDon D Sin
Jul 28, 2017·Canadian Journal of Physiology and Pharmacology·Jan SlezakNarcis Tribulova
Sep 9, 2017·Journal of Dental Anesthesia and Pain Medicine·Ji-Young YoonChang-Hoon Park
Nov 9, 2018·Archives of Microbiology·Vinaya Kizhakkepatt Kizhakkekalam, Kajal Chakraborty
Oct 27, 2020·Aging Medicine·Davide Gorni, Annarosa Finco

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