Free radicals in cerebral ischemia

Stroke; a Journal of Cerebral Circulation
E S FlammJ Ransohoff

Abstract

The possibility that cerebral ischemia may initiate a series of pathological free radical reactions within the membrane components of the CNS was investigated in the cat. The normally occurring electron transport radicals require adequate molecular oxygen for orderly transport of electrons and protons. A decrease in tissue oxygen removes the controls over the electron transport radicals, and allows them to initiate pathologic radical reactions among cell membranes such as mitochondria. Pathologic radical reactions result in multiple products, each of which may be present in too small a concentration to permit their detection at early time periods. It is possible to follow the time course, however, by the decrease of a major antioxidant as it is consumed by the pathologic radical reactions. For this reason, ascorbic acid was measured in ischemic and control brain following middle cerebral artery occlusion. There was a progressive decrease in the amount of detectable ascorbic acid ranging from 25% at 1 hour to 65% at 24 hours after occlusion. The reduction of this normally occurring antioxidant and free radical scavenger may indicate consumption of ascorbic acid in an attempt to quench pathologic free radical reactions occurring ...Continue Reading

References

Jan 1, 1996·Lasers in Surgery and Medicine·T IwaseD O Carpenter
Oct 29, 2002·Annals of Neurology·Erin P Flynn, Roland N Auer
Aug 1, 1994·Pediatric Pulmonology·R SchneidermanM Delivoria-Papadopoulos
May 1, 1989·Biulleten' eksperimental'noĭ biologii i meditsiny·M B PlotnikovO P Panina
Apr 1, 1982·Neurochemical Research·K KogureK Abe
Jun 1, 1992·Neurochemical Research·J X Wilson, E M Jaworski
Mar 25, 2000·Biulleten' eksperimental'noĭ biologii i meditsiny·A B SmirnovO P Mironova
Oct 1, 1996·Biological Trace Element Research·T MinamiY Okazaki
Nov 1, 1994·Irish Journal of Medical Science·P C SharpeT Trinick
Jan 1, 1983·Canadian Anaesthetists' Society Journal·N G Caseby
Apr 12, 2008·Journal of Natural Medicines·Kazutoshi ShindoYukiko Koike
Jan 21, 2012·Journal of Natural Medicines·Shinichi HaradaShogo Tokuyama
Oct 28, 1996·Brain Research·J Kume-KickM E Rice
Apr 29, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·Z S HuangT K Lee
Dec 1, 1985·Experimental Neurology·W PaschenL Csiba
Mar 1, 1992·Journal of the Neurological Sciences·M F BealE D Bird
Jan 1, 1994·Life Sciences·N GruenerM Barak
Oct 1, 1991·Trends in Neurosciences·S G WaxmanP K Stys
May 1, 1989·Archives of Gerontology and Geriatrics·M Suno, A Nagaoka
Jun 1, 1993·Progress in Neurobiology·H HaraK Kogure

Citations

Mar 1, 1977·Journal of Neurosurgery·E S FlammJ Ransohoff
Jul 1, 1972·Journal of Neurosurgery·V D MacDonaldR K Winkelmann
Dec 1, 1973·Archives of Neurology·J B BrierleyA W Brown
Dec 31, 1973·Annals of the New York Academy of Sciences·P MilvyH B Demopoulos
Jul 1, 1973·Journal of Neuropathology and Experimental Neurology·V W Fischer, J S Nelson
Oct 1, 1973·Archives of Neurology·L G SalfordB K Siesjö
Dec 1, 1973·Archives of Neurology·E G Fischer
Dec 1, 1973·Archives of Neurology·B K Siesjö, B Ljunggren
Sep 1, 1969·Journal of Neurosurgery·T M SundtJ H Garcia

Related Concepts

Dioxygen
Infarction, Middle Cerebral Artery
Brain
Antioxidants
Electron Transport
Free Radicals
Radicals (chemistry)
Ascorbic Acid Measurement
Mitochondria
Obstruction

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