Free radicals run in lizard families.

Biology Letters
Mats OlssonThomas Wanger

Abstract

In the ageing individual, the production of reactive oxygen species (ROS) accelerates with cell senescence. Depending on the heritability of the underlying processes that determine net ROS levels, this may influence ageing per se and its evolutionary direction and rate of change. In order to understand the inheritance and evolution of net ROS levels in free-ranging lizards, we used flow cytometry together with ROS-sensitive fluorogenic probes to measure ROS in lizard blood cells. We measured basal levels of (i) non-specific ROS (superoxide, singlet oxygen, H2O2 and peroxynitrite), (ii) superoxide specifically and (iii) superoxide after CCCP treatment, which elevated ROS production in the mitochondria. The cumulative level of non-specific ROS was higher in adults than juveniles and superoxide level showed high heritability and variability among families. We suggest that the evolution of ROS dynamics may be ROS species specific and perhaps depend on the relative degree of uni- or biparental inheritance of ROS main regulatory pathways.

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Citations

Mar 25, 2009·Die Naturwissenschaften·Mats OlssonTobias Uller
Jul 10, 2012·Die Naturwissenschaften·Cissy BallenMats Olsson
Mar 28, 2009·Biology Letters·Francois Criscuolo, Frederic Bouillaud
Jun 3, 2011·Biology Letters·Michael ToblerMats Olsson
Mar 28, 2009·Proceedings. Biological Sciences·Damian K Dowling, Leigh W Simmons
Feb 1, 1964·The Australian and New Zealand Journal of Surgery·T Pirotta
Jun 21, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Natalya S Zinkevich, David D Gutterman
Jul 24, 2014·Heredity·S ReichertS Massemin
Sep 9, 2011·Journal of Evolutionary Biology·S LosdatH Richner
Feb 13, 2010·Journal of Evolutionary Biology·S-Y KimA Velando
Sep 15, 2015·PloS One·Giuseppina Di GiacomoGabriele Gentile
May 6, 2015·PloS One·Michael ToblerMats Olsson
Jul 28, 2018·Integrative and Comparative Biology·Pablo SalmónCaroline Isaksson
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Reinald Pamplona, David Costantini
May 23, 2019·Molecular Biology of the Cell·Lukasz SamlukAgnieszka Chacinska
Sep 15, 2020·Functional Ecology·Luke A HoekstraAnne M Bronikowski
May 13, 2020·The Journal of Experimental Biology·Willow R LindsayMats Olsson
Oct 20, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christopher R FriesenMats Olsson
Apr 1, 2021·The Journal of Experimental Biology·Christopher R FriesenMats Olsson

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