Free testosterone level correlated with the metabolic abnormalities dependent on central obesity in women with polycystic ovary syndrome

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Z DongD Yang

Abstract

Women with polycystic ovary syndrome (PCOS) have increased risks of developing metabolic abnormalities compared with the women without PCOS. Hyperandrogenemia is one of the most important characteristics of PCOS. However, the correlations between hyperandrogenemia and metabolic disorders are uncertain. To elucidate the relationship between androgen indices and metabolic abnormalities in Chinese women with PCOS. A retrospective analysis of the anthropometric and biochemical records of 408 women with PCOS. The prevalence of metabolic syndrome (MetS) was 15.7% in women with PCOS. No association existed between total testosterone (TT) and metabolic profile. Free testosterone (FT) correlated with most of the metabolic variables by unadjusted correlation analyses. The women with elevated FT levels exhibited more unfavorable metabolic profiles compared with the women with normal FT levels. After adjusting for the confounding factors by multivariate logistic regression analysis, the women with elevated FT levels had higher prevalence of central obesity than the women with normal FT levels (odds ratio [OR] 2.346, p=0.042). Women with reduced sex hormone-binding globulin levels were more likely to have central obesity, overweight, raised...Continue Reading

Citations

May 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Nilgün Güdücüİlkkan Dünder
May 15, 2013·Reproductive Biomedicine Online·E A M KuijperC B Lambalk
Oct 28, 2019·Climacteric : the Journal of the International Menopause Society·A T Ali, F Guidozzi

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