Abstract
Emerging evidence suggests that mildly down-regulated thyroid function in older persons may protect and/or reflect maintained health. Using observational data collected between January 2006 and March 2014 on a volunteer sample of 602 men and women aged 68-97 years with normal thyroid function participating in the Baltimore Longitudinal Study of Aging, this study examines the concurrent relationship between reported walking ability, usual and rapid gait speed, endurance walk performance, fatigability, and reported energy level with respect to free thyroxine (FT4) within the normal range (0.76-1.50ng/dL) as a continuous variable and categorized as low (lower quartile), medium (interquartile), or high (upper quartile). Adjusting for sex, age, race, height, weight, exercise and smoking, reported walking ability, usual and rapid gait speed, 400-m time, fatigability, and reported energy level were less favorable with increasing FT4 (p = .013 to <.001). In sex-strata, similar associations were observed except for walking ability in men and energy level in women. Categorical analyses revealed that persons with low FT4 exhibited better functional mobility, fitness, and reported energy than persons with intermediate or high levels (p < ....Continue Reading
References
Jan 1, 1990·Scandinavian Journal of Work, Environment & Health·G Borg
Mar 2, 1995·The New England Journal of Medicine·J M GuralnikR B Wallace
Mar 1, 1996·Medical Care·J WareS D Keller
Oct 5, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·E M SimonsickUNKNOWN Health ABC Study Group
Aug 6, 2002·Science·George S RothE Jeffrey Metter
Aug 6, 2003·Annals of Internal Medicine·J Enrique Silva
Dec 2, 2004·JAMA : the Journal of the American Medical Association·Jacobijn GusseklooRudi G J Westendorp
Sep 22, 2005·The Journal of Clinical Endocrinology and Metabolism·Annewieke W van den BeldSteven W J Lamberts
Jan 20, 2006·Journal of the American Geriatrics Society·Eleanor M SimonsickJerome L Fleg
Jul 11, 2007·Archives of Internal Medicine·Bjørn O AsvoldLars J Vatten
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Martin I Surks, Joseph G Hollowell
Jul 22, 2008·Psychoneuroendocrinology·Eef HogervorstCarol Brayne
Aug 12, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Carmelinda RuggieroLuigi Ferrucci
Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Gil AtzmonIlan Gabriely
Nov 26, 2009·Archives of Internal Medicine·Eleanor M SimonsickUNKNOWN Health ABC Study
Dec 19, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maarten P RozingUNKNOWN Leiden Longevity Study (LLS) Group
Mar 20, 2010·European Journal of Endocrinology·Rudolf HoermannRolf Larisch
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Basil A Eldadah
Jan 26, 2012·Lancet·David S Cooper, Bernadette Biondi
Jan 31, 2012·Journal of Clinical Pathology·Penny M ClarkJayne A Franklyn
Feb 22, 2012·The Journal of Clinical Endocrinology and Metabolism·Alexandra P BremnerJohn P Walsh
Aug 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Avantika C WaringAnne R Cappola
Sep 15, 2012·The Journal of Clinical Endocrinology and Metabolism·Bu B YeapOsvaldo P Almeida
Oct 6, 2012·Journal of the American Geriatrics Society·Jennifer A SchrackLuigi Ferrucci
May 15, 2013·The Journal of Clinical Endocrinology and Metabolism·Narelle C HadlowJohn P Walsh
Jul 16, 2013·European Journal of Endocrinology·Bu B YeapS A Paul Chubb
Oct 3, 2013·European Journal of Endocrinology·Greet RoefJean-Marc Kaufman
Jan 15, 2014·Journal of the American Geriatrics Society·Eleanor M SimonsickLuigi Ferrucci
Mar 19, 2014·Journal of the American Geriatrics Society·Jennifer A SchrackLuigi Ferrucci
Nov 21, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elisa FabbriLuigi Ferrucci
Dec 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Anne R CappolaBruce M Psaty
Apr 22, 2015·JAMA Internal Medicine·Bjørn O ÅsvoldUNKNOWN Thyroid Studies Collaboration
Feb 7, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer A SchrackLuigi Ferrucci
Citations
Jul 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Katherine S HallMiriam C Morey
Oct 21, 2016·European Journal of Endocrinology·Amit AkirovIlan Shimon
Jul 22, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Bu B YeapLeon Flicker
Aug 31, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rita OstanGiovanni Vitale
Nov 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Simon H S PearceCarol Jagger
Dec 15, 2016·Scientific Reports·Arjola BanoRobin P Peeters
Sep 14, 2019·Aging·Livia López-NoriegaAlejandro Martin-Montalvo
Sep 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer A SchrackNancy W Glynn
Aug 21, 2019·Thyroid : Official Journal of the American Thyroid Association·Dominik SpiraTill Ittermann
Mar 12, 2020·Arquivos de neuro-psiquiatria·Davi Vilela CarvalhoPaula Luciana Scalzo
Nov 9, 2018·Journal of Endocrinological Investigation·G P EmerenzianiA Aversa
Oct 14, 2020·Aging Cell·Benoit R GauthierAlejandro Martin-Montalvo
Oct 6, 2020·Thyroid : Official Journal of the American Thyroid Association·Robert S Du PuyJacobijn Gussekloo
Oct 22, 2019·Current Opinion in Endocrine and Metabolic Research·Jennifer S Mammen
Nov 25, 2021·European Geriatric Medicine·Aline S da S CorreiaPatricia F S Teixeira