Free thyroxine levels are associated with cognitive changes in individuals with a first episode of psychosis: A prospective 1-year follow-up study

Schizophrenia Research
Javier LabadElisabet Vilella

Abstract

The results of previous cross-sectional studies suggest that free thyroxine (FT4) levels are associated with cognitive abilities (particularly attention/vigilance) during the early stages of psychosis. We aimed to explore whether hypothalamic-pituitary-thyroid hormones predict cognitive changes in a 1-year longitudinal study following first episodes of psychosis (FEP). We studied 36 FEP patients and a control group of 50 healthy subjects (HS). Plasma levels of thyroid-stimulating hormone (TSH) and FT4 were measured. Cognitive assessment was performed with the MATRICS Cognitive Consensus Cognitive Battery (MCCB). FEP patients were assessed twice (baseline and after 1year), whereas HS were assessed only once. We compared cognitive changes at 1year between three groups based on baseline FT4 levels: 1) lowest quartile (Q1, FT4<1.16ng/dL); 2) medium quartiles (Q2-Q3, FT4 1.16-1.54ng/dL); and 3) highest quartile (Q4, FT4>1.54ng/dL). No differences in TSH or FT4 levels were found between HS and FEP patients. All participants had FT4 levels within the normal range. HS outperformed FEP patients in all cognitive tasks. In relation to the relationship between FT4 levels and cognitive changes, a U-shaped pattern was observed: FEP patients ...Continue Reading

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May 20, 2015·Schizophrenia Research·Juan D BarberoJavier Labad

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Citations

Sep 19, 2019·Early Intervention in Psychiatry·Juan D BarberoJavier Labad
Dec 1, 2018·Journal of Veterinary Internal Medicine·Alenka HrovatSylvie Daminet
Dec 29, 2020·Early Intervention in Psychiatry·Regina Vila-BadiaJudith Usall
Jun 15, 2021·Psychiatry Research·A Casado-OrtegaUNKNOWN G. PROFEP and J. Usall
Jul 19, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Błażej MisiakDorota Frydecka

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