Free Total Rhubarb Anthraquinones Protect Intestinal Injury via Regulation of the Intestinal Immune Response in a Rat Model of Severe Acute Pancreatitis

Frontiers in Pharmacology
Yuxia XiongShousong Cao

Abstract

Intestinal mucosal immune barrier dysfunction plays a key role in the pathogenesis of severe acute pancreatitis (SAP). Rhubarb is a commonly used traditional Chinese medicine as a laxative in China. It markedly protects pancreatic acinar cells from trypsin-induced injury in rats. Free total rhubarb anthraquinones (FTRAs) isolated and extracted from rhubarb display the beneficial effects of antibacteria, anti-inflammation, antivirus, and anticancer. The principal aim of the present study was to investigate the effects of FTRAs on the protection of intestinal injury and modification of the intestinal barrier function through regulation of intestinal immune function in rats with SAP. We established a rat model of SAP by injecting 3.5% sodium taurocholate (STC, 350 mg/kg) into the biliopancreatic duct via retrograde injection and treated the rats with FTRAs (36 or 72 mg/kg) or normal saline (control) immediately and 12 h after STC injection. Then, we evaluated the protective effect of FTRAs on intestinal injury by pathological analysis and determined the levels of endotoxin (ET), interleukin 1β (IL-1β), tumor necrosis factor α (TNF-α), nitric oxide (NO), myeloperoxidase (MPO), capillary permeability, nucleotide-binding oligomerizat...Continue Reading

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Citations

Mar 19, 2020·JPEN. Journal of Parenteral and Enteral Nutrition·Xinrong ChenKa Li
Aug 31, 2020·Chinese Medicine·Hong XiangDeshi Dong
Sep 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Wenyin Jin, Yinfeng Shen
Mar 20, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ge LiangQing Xia
May 11, 2021·Frontiers in Pharmacology·Zixuan LiuXianli Meng

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Methods Mentioned

BETA
ELISA
flow cytometry

Software Mentioned

LabSolutions
SPSS

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