Free-Water Imaging in White and Gray Matter in Parkinson's Disease

Cells
Christina AndicaShigeki Aoki

Abstract

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson's disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased FW-corrected mean, axial, and radial diffusivities (MDT, ADT, and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with PD showed significantly lower FAT and higher MDT, ADT, and RDT (indices of neuronal degeneration) in anterior WM areas as well as higher FW (index of neuroinflammation) in posterior WM areas compared with the controls. Results of GM-based spatial statistics (GBSS) analysis revealed that patients with PD had significantly higher MDT, ADT, and FW than the controls, whereas ROI analysis showed significantly increased MDT and FW and a trend toward increased ADT in GM areas, corresponding to Braak stage IV. These findings support the hypothesis th...Continue Reading

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Citations

Dec 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Christina AndicaShigeki Aoki
Mar 27, 2020·Neural Regeneration Research·Koji KamagataShigeki Aoki
Dec 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marc GolubRita Gouveia Nunes
Apr 17, 2021·Scientific Reports·Md Nasir UddinGiovanni Schifitto
Jun 3, 2021·International Journal of Molecular Sciences·Koji KamagataShigeki Aoki
Jul 30, 2021·Parkinsonism & Related Disorders·Takashi OgawaNobutaka Hattori
Oct 31, 2021·NPJ Parkinson's Disease·Takashi OgawaNobutaka Hattori

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Software Mentioned

FMRIB Software Library
DARTEL
FMRIB
EDDY
SPSS Statistics
MATLAB
TBSS
FSL
TOPUP
Statistical Parametric Mapping

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