Freedom of movement and the stability of its unfolding in free exploration of mice.

Proceedings of the National Academy of Sciences of the United States of America
Ehud FonioIlan Golani

Abstract

Exploration is a central component of human and animal behavior that has been studied in rodents for almost a century. The measures used by neuroscientists to characterize full-blown exploration are limited in exposing the dynamics of the exploratory process, leaving the morphogenesis of its structure and meaning hidden. By unfettering exploration from constraints imposed by hunger, thirst, coercion, and the confines of small cage and short session, using advanced computational tools, we reveal its meaning in the operational world of the mouse. Exploration consists of reiterated roundtrips of increasing amplitude and freedom, involving an increase in the number of independent dimensions along which the mouse moves (macro degrees of freedom). This measurable gradient can serve as a standard reference scale for the developmental dynamics of some aspects of the mouse's emotional-cognitive state and for the study of the interface between behavior and the neurophysiologic and genetic processes mediating it.

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Citations

Jan 5, 2013·Behavior Genetics·Timothy P O'LearyRichard E Brown
Dec 12, 2012·Nature Methods·Ehud FonioYoav Benjamini
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dina Lipkind, Ofer Tchernichovski
Mar 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yoav BenjaminiIlan Golani
Jan 22, 2010·PLoS Computational Biology·Anna DvorkinIlan Golani
Apr 10, 2012·PloS One·Jean-Baptiste PassotAngelo Arleo
Nov 3, 2012·PloS One·Ehud FonioIlan Golani
Apr 24, 2014·PloS One·Oded Berger-TalDavid Saltz
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Mar 11, 2016·Journal of Neurophysiology·James J JunLeonard Maler
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Apr 17, 2018·Royal Society Open Science·Yair WexlerIlan Golani
Dec 8, 2020·Frontiers in Behavioral Neuroscience·Tzviel FrostigIlan Golani
Jun 22, 2021·Frontiers in Behavioral Neuroscience·Ismail Nurul ImanMustapha Muzaimi

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