Freeze-all policy: fresh vs. frozen-thawed embryo transfer

Fertility and Sterility
Matheus RoqueSelmo Geber

Abstract

To compare in vitro fertilization (IVF) outcomes between fresh embryo transfer (ET) and frozen-thawed ET (the "freeze-all" policy), with fresh ET performed only in cases without progesterone (P) elevation. Prospective, observational, cohort study. Private IVF center. A total of 530 patients submitted to controlled ovarian stimulation (COS) with a gonadotropin-releasing hormone-antagonist protocol, and cleavage-stage, day-3 ET. None. Ongoing pregnancy rates. A total of 530 cycles were included in the analysis: 351 in the fresh ET group (when P levels were ≤1.5 ng/mL on the trigger day); and 179 cycles in the freeze-all group (ET performed after endometrial priming with estradiol valerate, at 6 mg/d, taken orally). For the fresh ET group vs. the freeze-all group, respectively, the implantation rate was 19.9% and 26.5%; clinical pregnancy rate was 35.9% and 46.4%; and ongoing pregnancy rate was 31.1% and 39.7%. The IVF outcomes were significantly better in the group using the freeze-all policy, compared with the group using fresh ET. These results suggest that even in a select group of patients that underwent fresh ET (P levels ≤1.5 ng/mL), endometrial receptivity may have been impaired by COS, and outcomes may be improved by usin...Continue Reading

References

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Citations

Jan 3, 2016·Human Reproduction·Christophe BlockeelHerman Tournaye
Feb 19, 2016·Systems Biology in Reproductive Medicine·Qiao-hua HeShi-hong Cui
Apr 29, 2015·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M A Coelho NetoP A Navarro
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Oct 8, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Marco Filicori
Aug 19, 2015·Fertility and Sterility·Lieselot DeleyeFilip Van Nieuwerburgh
Aug 10, 2015·Fertility and Sterility·Bruce S ShapiroCynthia Hudson
Nov 21, 2015·Journal of Ovarian Research·Stefano PalombaGiovanni Battista La Sala
Jun 6, 2016·Fertility and Sterility·Daniela Paes Almeida Ferreira BragaEdson Borges
Apr 10, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Sarah NejdetAnn Thurin-Kjellberg
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Sep 16, 2016·Journal of Assisted Reproduction and Genetics·Natalia Basile, Juan A Garcia-Velasco
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Nov 7, 2016·Journal of Assisted Reproduction and Genetics·Matheus RoqueSelmo Geber
Feb 22, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yamei XueSongying Zhang
Dec 28, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·M RoqueS Geber
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Jul 16, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Sita GarimellaDurga Rao Gedela
Mar 17, 2017·Journal of Assisted Reproduction and Genetics·Samer TannusMichael Haim Dahan
Apr 19, 2019·Reproductive Medicine and Biology·Yoshimasa AsadaYoshiki Hashiba
Jul 23, 2015·Reproductive Medicine and Biology·Misato ShimodaMasanori Yamashita
Mar 11, 2020·Frontiers in Endocrinology·Ernesto BoschPeter Humaidan

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