Freeze-cast Porous Chitosan Conduit for Peripheral Nerve Repair

MRS Advances
Kaiyang YinUlrike G K Wegst

Abstract

A novel freeze-cast porous chitosan conduit for peripheral nerve repair with highly-aligned, double layered porosity, which provides the ideal mechanical and chemical properties was designed, manufactured, and assessed in vivo. Efficacies of the conduit and the control inverted nerve autograft were evaluated in bridging 10-mm Lewis rat sciatic nerve gap at 12 weeks post-implantation. Biocompatibility and regenerative efficacy of the porous chitosan conduit were evaluated through the histomorphometric analysis of longitudinal and transverse sections. The porous chitosan conduit was found to have promising regenerative characteristics, promoting the desired neovascularization, and axonal ingrowth and alignment through a combination of structural, mechanical and chemical cues.

References

Mar 24, 2010·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Ulrike G K WegstPhilipp M Hunger
Jan 17, 2013·Acta Biomaterialia·Philipp M HungerUlrike G K Wegst
Sep 21, 2013·Biomaterials·Kirsten Haastert-TaliniClaudia Grothe
Feb 25, 2014·Biomaterials·Federica CerriAngelo Quattrini
Oct 27, 2014·Nature Materials·Ulrike G K WegstRobert O Ritchie

❮ Previous
Next ❯

Citations

Jul 28, 2019·Journal of Tissue Engineering and Regenerative Medicine·Maliheh JahromiAbbas Bakhtiari
Oct 28, 2019·Annals of Biomedical Engineering·Amir RouhollahiHassan Foroosh
Apr 10, 2020·Angewandte Chemie·Satoru TakeshitaMatthias M Koebel
Nov 5, 2019·Acta Biomaterialia·Herleen RupraiAntonio Lauto
Nov 13, 2020·Frontiers in Bioengineering and Biotechnology·Benedetta E FornasariStefania Raimondo
Jun 15, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Kaiyang YinUlrike G K Wegst
Jul 9, 2021·PLoS Computational Biology·Rachel CoyRebecca J Shipley
Aug 3, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Cleo ParisiFrancisco M Fernandes
Aug 25, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Tongxin ZhangJincheng Wang
Sep 24, 2020·ACS Applied Materials & Interfaces·Silas Owusu-Nkwantabisah, Jeffrey Gillmor

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.