Freeze-casting for PLGA/carbonated apatite composite scaffolds: Structure and properties

Materials Science & Engineering. C, Materials for Biological Applications
M SchardosimC Combes

Abstract

This paper focuses on the fabrication of three-dimensional porous PLGA-biomimetic carbonated apatite composite scaffolds by freeze-casting and using dimethyl carbonate as a solvent. Several charge/polymer ratios were tested in order to finely understand the influence of the filler rate on the scaffold porosity and mechanical and degradation properties using complementary characterization techniques (SEM, mercury porosimetry and X-ray microtomography). It was demonstrated that the apatite ratio within the composite scaffold has a strong influence in terms of architecture, material cohesion, mechanical properties and in vitro degradation properties. An optimum biomimetic apatite ratio was reached to combine good mechanical properties (higher rigidity) and material cohesion. In vitro degradation studies showed that higher apatite filler rates limited PLGA degradation and enhanced the hydrophilicity of the scaffolds which is expected to improve the biological properties of the scaffolds in addition to the bioactivity related to the presence of the apatite analogous to bone mineral.

Citations

Apr 6, 2020·Biotechnology and Applied Biochemistry·Hessam RezaeiMohammadali Sahebalzamani
Nov 25, 2017·Advanced Healthcare Materials·Cláudia MartinsBruno Sarmento
Aug 24, 2018·Nanomaterials·Denisa FicaiEcaterina Andronescu
Apr 13, 2021·Journal of Tissue Engineering and Regenerative Medicine·Munusamy RamadasAnbalagan M Ballamurugan
Jul 3, 2021·European Annals of Otorhinolaryngology, Head and Neck Diseases·P LagarrigueA Dupret-Bories
Jan 6, 2022·Macromolecular Bioscience·María I Alvarez EchazúMartín F Desimone

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