Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery

Carbohydrate Polymers
Marzia MarcielloCarmen Remuñán-López

Abstract

Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines or microbicides to prevent or treat sexually transmitted diseases. In this work, a straightforward and efficient strategy for the vaginal application and release of peptide-loaded mucoadhesive nanoparticles was developed. This essentially consists of chitosan nanoparticles encapsulated in suitable hydrophilic freeze-dried cylinders. Chitosan nanoparticles are responsible for carrying the peptide drug and allowing adhesion to the vaginal mucosal epithelium. Hydrophilic freeze-dried cylinders facilitate the application and quick release of the nanoparticles to the vaginal zone. Upon contact with the aqueous vaginal medium, the excipients constituting these sponge-like systems are quickly dissolved enabling the release of their content. In vitro release studies showed the ability of the sponge-like systems and chitosan nanoparticles to deliver the mucoadhesive nanoparticles and peptide respectively. CLSM micrographs proved the nanoparticles ability promoting the peptide penetration inside the vaginal mucosa.

Citations

Aug 6, 2019·Advanced Pharmaceutical Bulletin·Unnati GargNeha Jain
Jun 9, 2018·International Journal of Molecular Sciences·Gerardo Leyva-GómezDavid Quintanar-Guerrero
Feb 4, 2021·Nanomaterials·Giulia ChindamoMarina Gallarate
Oct 11, 2017·Advanced Drug Delivery Reviews·Lei WuYuan Huang
Dec 21, 2020·Advances in Colloid and Interface Science·Joëlle Bizeau, Damien Mertz
May 1, 2021·Pharmaceutics·Andreea Teodora IacobLenuta Profire
Jul 3, 2021·Pharmaceutics·Tomasz OsmałekBozena Michniak-Kohn
Sep 11, 2021·International Journal of Molecular Sciences·Veronika Mikušová, Peter Mikuš

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