Freeze-dried plasma enhances clot formation and inhibits fibrinolysis in the presence of tissue plasminogen activator similar to pooled liquid plasma

Transfusion
Benjamin R HuebnerChristopher C Silliman

Abstract

Systemic hyperfibrinolysis is an integral part of trauma-induced coagulopathy associated with uncontrolled bleeding. Recent data suggest that plasma-first resuscitation attenuates hyperfibrinolysis; however, the availability, transport, storage, and administration of plasma in austere environments remain challenging and have limited its use. Freeze-dried plasma (FDP) is a potential alternative due to ease of storage, longer shelf life, and efficient reconstitution. FDP potentially enhances clot formation and resists breakdown better than normal saline (NS) and albumin and similar to liquid plasma. Healthy volunteers underwent citrated blood draw followed by 50% dilution with NS, albumin, pooled plasma (PP), or pooled freeze-dried plasma (pFDP). Citrated native and tissue plasminogen activator (t-PA)-challenge (75 ng/mL) thrombelastography were done. Proteins in PP, pFDP, and albumin were analyzed by mass spectroscopy. pFDP and PP had superior clot-formation rates (angle) and clot strength (maximum amplitude) compared with NS and albumin in t-PA-challenge thrombelastographies (angle: pFDP, 67.9 degrees; PP, 67.8 degrees; NS, 40.6 degrees; albumin, 35.8 degrees; maximum amplitude: pFDP, 62.4 mm; PP, 63.5 mm; NS, 44.8 mm; albumin,...Continue Reading

References

May 28, 2004·The New England Journal of Medicine·Simon FinferUNKNOWN SAFE Study Investigators
Sep 1, 2007·The New England Journal of Medicine·UNKNOWN SAFE Study InvestigatorsShirley Vallance
May 13, 2008·The Journal of Trauma·Karim BrohiJean-François Pittet
Oct 4, 2008·Current Opinion in Hematology·Bjarte G SolheimOystein Flesland
Apr 21, 2009·Nature Methods·Jacek R WiśniewskiMatthias Mann
Aug 27, 2010·Annals of Surgery·Jeffry L KashukAngela Sauaia
Aug 24, 2011·The Journal of Trauma·Kenji Inaba
Jun 29, 2012·Anesthesiology·Christophe MartinaudAnne Sailliol
Aug 1, 2012·The Journal of Trauma and Acute Care Surgery·Bryan A CottonNena Matijevic
Feb 15, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vadim KostousovNena Matijevic
Apr 16, 2013·Transfusion·Jürgen BuxEdgar Scheel
Aug 15, 2013·The Journal of Trauma and Acute Care Surgery·Deborah J del JuncoUNKNOWN PROMMTT Study Group
Jun 20, 2015·The Journal of Trauma and Acute Care Surgery·Sean P McCullyMartin A Schreiber
Dec 19, 2015·The Journal of Trauma and Acute Care Surgery·Hunter B MooreChristopher C Silliman

❮ Previous
Next ❯

Citations

Sep 18, 2017·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·M J MadurskaJ J Morrison
Dec 6, 2020·The Journal of Surgical Research·Gregory R StettlerChristopher C Silliman
Sep 8, 2020·Vox Sanguinis·Gregory R StettlerChristopher C Silliman
Jul 17, 2021·Transfusion·Henry T PengAndrew Beckett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The Journal of Trauma and Acute Care Surgery
Hunter B MooreChristopher C Silliman
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Vadim KostousovNena Matijevic
Postȩpy higieny i medycyny doświadczalnej
M Wilczyńska, C Cierniewski
Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Gustav Folmer GenétPär I Johansson
© 2022 Meta ULC. All rights reserved