PMID: 7013113Mar 1, 1981Paper

Freeze fracture electron microscopical investigation of Candida albicans cells sensitive and resistant to nystatin

Sabouraudia
Miklós PestiA Svoboda

Abstract

A sterol mutant was isolated after nitrosoguanidine treatment, on the basis of th nystatin-resistant phenotypic behaviour, from a Candida albicans strain requiring adenine. The plasma membrane ultrastructure of the resistant mutant, observed by freeze-fracture electron microscopy, was not significantly different from the parental, ergosterol producing nystatin-sensitive strain. Nystatin treatment caused no ultrastructural change in the resistant strain, but led to the aggregation of membrane particles in the sensitive strain: this effect was considered to be the specific effect of nystatin. Other, probably nonspecific effects of nystatin on the sensitive strain were a deepening and deformation of invaginations, atypical membrane fracture, certain changes in the structure of cell wall and special ornamentation of its surface. No change in the intracellular membranes was observed.

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Citations

Sep 14, 1999·FEMS Microbiology Letters·K Czakó-VérM Pesti
Nov 9, 2016·Apoptosis : an International Journal on Programmed Cell Death·Ágnes BlaskóMiklós Pesti
Jan 1, 1987·Critical Reviews in Microbiology·M G Shepherd

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