Abstract
Affective "Theory of Mind" (ToM) is the specific ability to represent own and others' emotional states and feelings. Several studies examined affective ToM ability in patients with Parkinson's disease (PD), using the "Reading the Mind in the Eyes test" (RMET). However, there has been no agreement as to whether or not affective ToM ability is impaired in PD and such discrepancy may be due to the heterogeneous clinical presentation of PD. Affective disturbance has been linked to the akinetic-rigid form of PD and to gait disturbances, like freezing of gait (FOG). Particularly, FOG has been associated with dysfunction in striatum ability of processing affective inputs. Here we hypothesized that the presence of FOG can be associated with impaired affective ToM ability in PD patients. We evaluated ToM by means of RMET and executive functions using the Tower Of London (ToL) test in 29 PD patients (15 with FOG and 14 without FOG) and 19 healthy age-matched subjects. Our results showed that affective ToM is abnormal in PD patients, compared to healthy subjects and that it is more impaired in patients with FOG than in patients without FOG. Further, PD patients with FOG performed worse than PD patients without FOG on the ToL test. The aff...Continue Reading
References
Mar 31, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·S Baron-CohenI Plumb
Feb 20, 2003·Neuropsychologia·J S SnowdenD Neary
Nov 17, 2006·Psychiatry Research·Simone G Shamay-TsooryYechiel Levkovitz
Jul 21, 2007·Neuropsychologia·Simone G Shamay-Tsoory, Judith Aharon-Peretz
Dec 15, 2007·Journal of the International Neuropsychological Society : JINS·J UekermannI Daum
Oct 11, 2008·Neuropsychologia·Julie PéronMarc Vérin
Jan 29, 2009·Experimental Aging Research·Matteo Pardini, Paolo F Nichelli
Aug 8, 2009·Gait & Posture·Alice NieuwboerNir Giladi
Jan 18, 2011·Behavioural Brain Research·Michele PolettiMauro Adenzato
Jul 23, 2011·Lancet Neurology·John G NuttAlice Nieuwboer
Aug 2, 2011·Neuropsychologia·Ahmad Abu-Akel, Simone Shamay-Tsoory
Nov 3, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Matteo PardiniLeonardo Cocito
May 21, 2013·Psychiatry and Clinical Neurosciences·Michele PolettiUbaldo Bonuccelli
Feb 12, 2014·JAMA Neurology·Mary Ann Thenganatt, Joseph Jankovic
Jun 20, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Olga Dal MonteFrank Krueger
Jan 8, 2015·Frontiers in Psychiatry·Michael James WeightmanBernhard Theodor Baune
Citations
Feb 13, 2016·Accident; Analysis and Prevention·Jennifer GeraghtyKim Rochelle
Aug 25, 2016·PloS One·Tom BurkeNiall Pender
Oct 25, 2016·Gait & Posture·Marianna CapecciMaria Gabriella Ceravolo
Oct 31, 2018·Scientific Reports·Rwei-Ling YuChun-Hsiang Tan
Jan 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ota GalEvzen Ruzicka
Jun 6, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Tom BurkeNiall Pender
Aug 24, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Ota GálEvžen Růžička
Aug 21, 2019·Parkinson's Disease·Ivan WittPenny MacDonald
Aug 10, 2020·Journal of Neural Transmission·Giovanna LagravineseLaura Avanzino
Jun 2, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Clare M Eddy, Jennifer L Cook
Jan 29, 2021·Parkinson's Disease·Ana Natalia Seubert-RaveloAdela Hernández-Galván
Aug 7, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Beatrice OrsoMatteo Pardini
Mar 25, 2021·Brain and Cognition·Maria Alice BaraldiGiovanna Lagravinese