Freezing of gait in early Parkinson's disease: Nigral iron content estimated from magnetic resonance imaging

Journal of the Neurological Sciences
Marguerite WielerW R Wayne Martin

Abstract

Freezing of gait is a major source of disability associated with the progression of Parkinson's disease (PD). Our objective was to determine whether evolving changes in nigral iron content in association with declining motor function in early PD differentiates subjects who develop freezing from those who do not. A cohort of previously untreated individuals with early PD (n=19) was followed for 36 months clinically and with MRI. The cohort was divided into two groups based on the development of freezing during follow-up. A multiple gradient echo MRI sequence provided an index of basal ganglia iron content. There were significant baseline differences between those who developed freezing (n=7) and those who did not (n=12) in Unified Parkinson's Disease Rating Scale motor scores, time to complete a 14 m walk and timed up and go. There was a significant correlation between the measured change in transverse relaxation in the lateral substantia nigra pars compacta and the change in motor score from baseline to 36 months (p=0.002). The freezing group showed a greater change in motor score and iron content than did the non-freezing group. Individuals destined to develop freezing early in PD have more motor impairment at baseline, more r...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Mar 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·A J HughesA J Lees
Feb 1, 1992·Neurology·N GiladiS Fahn
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jun 1, 1994·Brain : a Journal of Neurology·C S LeeD B Calne
Jul 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·F Q YeP S Allen
May 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·N GiladiS Fahn
Aug 17, 1999·Journal of Neurology, Neurosurgery, and Psychiatry·M A HelyP M Williamson
May 19, 2000·Parkinsonism & Related Disorders·N GiladiA D Korczyn
Jun 27, 2001·Neurology·N GiladiUNKNOWN Parkinson Study Group
Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Robert A Hauser, Nicholas H G Holford
Nov 6, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jim M WildPeter S Allen
Oct 16, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGeorg Becker
Aug 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Orna MooreNir Giladi
Feb 2, 2008·Annals of Neurology·W R Wayne MartinMichael Schulzer
Oct 23, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Inge LimGert Kwakkel
Dec 30, 2008·AJNR. American Journal of Neuroradiology·E S ManovaE M Haacke
Jul 17, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·W R Wayne MartinRichard Camicioli
Nov 12, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Claire L TomlinsonCarl E Clarke
Jun 28, 2011·Archives of Physical Medicine and Rehabilitation·Dawn M TanMeg E Morris
Oct 12, 2011·Journal of Magnetic Resonance Imaging : JMRI·Ashley K LotfipourNin P S Bajaj
Jan 31, 2012·Experimental Neurology·Robert E Burke, Karen O'Malley

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Citations

Oct 25, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Hui HuangYi Hu
Oct 13, 2017·Expert Review of Neurotherapeutics·Kurt A Jellinger
Jun 8, 2018·Current Opinion in Neurology·Vittorio RispoliKailash P Bhatia
Apr 1, 2017·Translational Neurodegeneration·Usman SaeedMario Masellis
Jul 8, 2017·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Huiru LuYi Hu
Oct 4, 2018·Current Neurology and Neuroscience Reports·Jing YangDavid E Vaillancourt
Nov 13, 2020·Frontiers in Neurology·Usman SaeedMario Masellis
Nov 8, 2017·Journal of the Neurological Sciences·Rajini M NaduthotaPramod Kumar Pal
Jul 3, 2021·Brain Sciences·Paola FeracoRoberto Monastero

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