Freezing of gait in Parkinson's disease is associated with altered functional brain connectivity

Parkinsonism & Related Disorders
Abhishek LenkaPramod Kumar Pal

Abstract

Patients with Parkinson's disease (PD) may develop several gait disturbances during the course of illness and Freezing of gait (FOG) is one of them. Several neuroimaging studies have been conducted to identify the neural correlates of FOG but results have not been uniform. Resting state functional MRI (rs-fMRI) is relatively less explored in PD patients with FOG. This study aims to compare the whole brain resting state connectivity of PD patients with and without FOG using rs-fMRI. rs-fMRI was obtained for 28 PD patients (15 with and 13 patients without FOG) who were matched for various demographic and clinical characteristics. Seed to voxel analysis was performed at whole brain level and compared between the two groups. When compared to patients without FOG, the patients with FOG had reduced functional connectivity across multiple seeds. Major finding was reduced inter-hemispheric connectivity of left parietal opercular cortex with multiple regions of the brain primarily involving the primary somatosensory and auditory areas, which also negatively correlated with the FOGQ scores. Our findings suggest that alterations in the resting state functional connectivity of the opercular parietal cortex may be one of the substrates of F...Continue Reading

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Citations

Feb 16, 2017·Neurorehabilitation and Neural Repair·Vera GramignaAldo Quattrone
Mar 1, 2018·Journal of Neuroengineering and Rehabilitation·Sara PizzamiglioDuncan L Turner
Mar 7, 2019·Movement Disorders Clinical Practice·Massimo FilippiFederica Agosta
Jun 16, 2017·BMC Bioinformatics·Marianna MilanoMario Cannataro
Apr 6, 2021·Current Neurology and Neuroscience Reports·Sule Tinaz
Dec 5, 2019·NeuroImage. Clinical·Komal BhartiPatrizia Pantano
Mar 14, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Wenjing SongGuiyun Cui
Jun 9, 2021·Neuroscience·Alexandra Potvin-Desrochers, Caroline Paquette
Sep 11, 2021·Neurorehabilitation and Neural Repair·Samuel StuartMartina Mancini

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