Frequencies and effects of alternative DRB3.2 alleles of bovine lymphocyte antigen for Holsteins in milk selection and control lines

Journal of Dairy Science
R J StarkenburgH Chester-Jones

Abstract

Frequencies of alleles at the DRB3.2 locus of the bovine major histocompatibility complex for two genetic lines of Holsteins were compared, and allelic effects on yield and udder health traits were examined. The DRB3.2 genotypes of 186 cows and heifers were determined using DNA that had been extracted from blood samples. The cattle were from a designed selection experiment for milk yield. After edits, 173 cows and heifers with known alleles remained (54 from a control line and 119 from a selection line for milk yield). A total of 19 alternative DRB3.2 alleles appeared across the two lines, and frequencies ranged from 0.3 to 21.4%. Allelic frequencies differed significantly between the selection and control lines. Alleles 3, 8, 9, 10, 26, and 28 were more frequent in the control line, but alleles 16, 24, and 27 were more frequent in the selection line. An animal model was used to estimate gene substitution effects of alternative alleles on milk yield, fat yield, and protein yield, SCS, chronically elevated SCS, acutely elevated SCS, and mastitis incidence. First, second, and third lactations were analyzed separately. Allele 7 was associated with a significant increase in protein yield during first and second lactations and a sig...Continue Reading

References

Jan 1, 1992·Animal Genetics·M J van EijkH A Lewin
Apr 1, 1992·Journal of Dairy Science·P J BoettcherC A Ernst
Dec 1, 1986·Journal of Dairy Science·H C HinesM M Michalak
Oct 1, 1994·Journal of Dairy Science·W P JonesH Chester-Jones
Jul 1, 1994·Journal of Dairy Science·M M Schutz
Oct 1, 1995·Journal of Dairy Science·J C DetilleuxD H Kelley

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Citations

Aug 19, 2016·The Journal of General Virology·Hironobu MurakamiKenji Tsukamoto
Oct 6, 1999·Journal of Dairy Science·B E GilliespieS P Oliver
Jan 30, 2002·Journal of Dairy Science·Y PanJ P Gibson
Jul 27, 2007·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·S KulbergI Olsaker
Feb 1, 2007·Pakistan Journal of Biological Sciences : PJBS·Morteza PashmiAbdolreza Salehi
Jul 28, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·M PashmiH Simianer
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Tatsuyuki YoshidaHiroshi Tomogane
Oct 15, 2011·Journal of Mammary Gland Biology and Neoplasia·Gina M Pighetti, A A Elliott
Apr 26, 2012·Molecular Biology Reports·L R BaltianG Giovambattista
Jun 6, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·A F da MotaL L Coutinho
Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Tatsuyuki YoshidaHiroshi Tomogane
May 12, 2012·Animal Science Journal = Nihon Chikusan Gakkaihō·Tatsuyuki YoshidaHarutaka Mukoyama
Jul 20, 2002·Veterinary Immunology and Immunopathology·J C Detilleux

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