Frequencies of CYP3A5 genotypes and haplotypes in a Korean population

Journal of Clinical Pharmacy and Therapeutics
S Y ParkK O Han

Abstract

CYP3A, the drug-metabolizing enzyme is an important factor in the pharmacokinetics of many drugs. Polymorphism of the CYP3A5 gene is known to influence the functionality of the CYP3A5 enzymes. The full extent of CYP3A5 genetic polymorphism was analysed in a Korean population. Specific polymerase chain reaction-restriction fragment length polymorphism tests for CYP 3AP1 through CYP3A5*7 or direct sequencing were used to identify reported CYP3A5 variant alleles, using 194 unrelated samples. The most frequent single nucleotide polymorphism (SNP) was 6986A>G (CYP3A5*3). The next most frequent SNP was 31611C>T. Haplotype analysis using detected SNPs revealed that the most frequent haplotype was *3A (frequency: 0.724), followed by *1E (frequency: 0.211), *3C (frequency: 0.034) and *1A (frequency: 0.023). We did not find CYP3AP1*3, CYP3A5*6, or *7 in this Korean sample. A large proportion of Koreans may have relatively low levels of metabolically active CYP3A5 protein and therefore may be at risk of high levels of drugs metabolized by this enzyme, after administration of conventional doses.

References

Sep 16, 1998·Human Molecular Genetics·B KeavneyM Farrall
Dec 12, 2001·Pharmacogenetics·E HustertL Wojnowski
Mar 27, 2002·The Pharmacogenomics Journal·D W Nebert, A G Menon
Jul 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J Andrew WilliamsSteven A Wrighton
Dec 31, 2002·Toxicology·Magnus Ingelman-Sundberg
May 21, 2003·European Journal of Clinical Pharmacology·C BalramEdmund J D Lee
May 25, 2006·Bioinformatics·Xavier SoléVíctor Moreno
Oct 13, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Su-Jun LeeRon H N van Schaik
Dec 13, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S QuarantaM Lhermitte

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Citations

Mar 13, 2012·Pharmacogenetics and Genomics·Jatinder LambaRuss B Altman
Dec 5, 2015·European Journal of Clinical Pharmacology·Khemjira YaowakulpatanaChagriya Kitiyakara
Jul 27, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Wei PanJae-Gook Shin
Oct 22, 2010·Angewandte Chemie·Sebastiano LicciulliKatrin Schuhen
Aug 12, 2014·Molecular Biology Reports·Gilberto Vargas-AlarcónJosé Manuel Fragoso
Oct 25, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Han RoCurie Ahn
Nov 17, 2020·AIDS Research and Human Retroviruses·Herana Kamal SeneviratneNamandje N Bumpus

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