Frequencies of poor metabolizers of cytochrome P450 2C19 in esophagus cancer, stomach cancer, lung cancer and bladder cancer in Chinese population

World Journal of Gastroenterology : WJG
Wei-Xing Shi, Shuqing Chen

Abstract

To investigate the association between cytochrome P450 2C19 (CYP2C19) gene polymorphism and cancer susceptibility by genotyping of CYP2C19 poor metabolizers (PMs) in cancer patients. One hundred and thirty-five cases of esophagus cancer, 148 cases of stomach cancer, 212 cases of lung cancer, 112 cases of bladder cancer and 372 controls were genotyped by allele specific amplification-polymerase chain reaction (ASA-PCR) for CYP2C19 PMs. The frequencies of PMs in cancer groups and control group were compared. The frequencies of PMs of CYP2C19 were 34.1%(46/135) in the group of esophagus cancer patients, 31.8%(47/148) in the stomach cancer patients, 34.4%(73/212) in the group of lung cancer patients, only 4.5%(5/112) in the bladder cancer patients and 14.0%(52/372) in control group. There were statistical differences between the cancer groups and control group (esophagus cancer, chi(2)=25.65, P<0.005, OR=3.18, 95%CI=2.005-5.042; stomach cancer, chi(2)=21.70, P<0.005, OR=2.86, 95%CI=1.820-4.501; lung cancer, chi(2)=33.58, P<0.005, OR=3.23, 95%CI=1.503-6.906; bladder cancer, chi(2)=7.50, P<0.01, OR=0.288, 95%CI=0.112-0.740). CYP2C19 PMs have a high incidence of esophagus cancer, stomach cancer and lung cancer, conversely they have a ...Continue Reading

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Citations

Aug 4, 2007·International Journal of Cancer. Journal International Du Cancer·Toru HiyamaKazuaki Chayama
Jun 12, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Le YaoZhao-Ming Xiong
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